ArticleBioMed research international2014
Sensoric protection after median nerve injury: babysitter-procedure prevents muscular atrophy and improves neuronal recovery.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- A myoneural actuator with engineered biophysics for implantable biohybrid systems.Nature communications · 2026Article
- Article
- Distal nerve transfers for median nerve reinnervation and hand function restoration.Brain & spine · 2026Article
- The Grasping Test Revisited: A Systematic Review of Functional Recovery in Rat Models of Median Nerve Injury.Biomedicines · 2022Review
- The Median Nerve Injury Model in Pre-clinical Research - A Critical Review on Benefits and Limitations.Frontiers in cellular neuroscience · 2019Review
- IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusion balance.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The babysitter-procedure might offer an alternative when nerve reconstruction is delayed in order to overcome muscular atrophy due to denervation. In this study we aimed to show that a sensomotoric babysitter-procedure after median nerve injury is capable of preserving irreversible muscular atrophy. The median nerve of 20 female Wistar rats was denervated. 10 animals received a sensory protection with the N. cutaneous brachii. After six weeks the median nerve was reconstructed by autologous nerve grafting from the contralateral median nerve in the babysitter and the control groups. Grasping tests measured functional recovery over 15 weeks. At the end of the observation period the weight of the flexor digitorum sublimis muscle was determined. The median nerve was excised for histological examinations. Muscle weight (P < 0.0001) was significantly superior in the babysitter group compared to the control group at the end of the study. The histological evaluation revealed a significantly higher diameter of axons (P = 0.0194), nerve fiber (P = 0.0409), and nerve surface (P = 0.0184) in the babysitter group. We conclude that sensory protection of a motor nerve is capable of preserving muscule weight and we may presume that metabolism of the sensory nerve was sufficient to keep the target muscle's weight and vitality.
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