ArticleBioMed research international2014
The role of neurotrophic factors conjugated to iron oxide nanoparticles in peripheral nerve regeneration: in vitro studies.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Mechanistic Advancements and Translational Progress in Hyaluronic Acid-Based Scaffolds and Conduits for Peripheral Nerve Regeneration.Journal of functional biomaterials · 2025Review
- Metal-Based Regenerative Strategies for Peripheral Nerve Injuries: From Biodegradable Ion Source to Stable Conductive Implants.Biomaterials research · 2025Review
- Nanotechnology Approaches for Prevention and Treatment of Chemotherapy-Induced Neurotoxicity, Neuropathy, and Cardiomyopathy in Breast and Ovarian Cancer Survivors.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- Nano-pulling stimulates axon regeneration in dorsal root ganglia by inducing stabilization of axonal microtubules and activation of local translation.Frontiers in molecular neuroscience · 2024Article
- Morphological Methods to Evaluate Peripheral Nerve Fiber Regeneration: A Comprehensive Review.International journal of molecular sciences · 2023Review
- In Vitro Models for the Development of Peripheral Nerve Conduits, Part I: Design of a Fibrin Gel-Based Non-Contact Test.Polymers · 2021Article
- Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2021Review
- Chitosan Functionalized Magnetic Nanoparticles to Provide Neural Regeneration and Recovery after Experimental Model Induced Peripheral Nerve Injury.Biomolecules · 2021Article
- Skin-Nerve Co-Culture Systems for Disease Modeling and Drug Discovery.Tissue engineering. Part C, Methods · 2021Review
- Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus.Neural regeneration research · 2021Article
- Magnetic particle templating of hydrogels: engineering naturally derived hydrogel scaffolds with 3D aligned microarchitecture for nerve repair.Journal of neural engineering · 2020Article
- Association of the Somatostatin Analog Octreotide With Magnetic Nanoparticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy.Frontiers in bioengineering and biotechnology · 2020Article
- Magnetic Composite Biomaterials for Neural Regeneration.Frontiers in bioengineering and biotechnology · 2019Review
- Tissue engineering for the repair of peripheral nerve injury.Neural regeneration research · 2019Review
- Magnetic Targeting of Growth Factors Using Iron Oxide Nanoparticles.Nanomaterials (Basel, Switzerland) · 2018Article
- Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte.BMC geriatrics · 2018Article
- Neurotrophin-conjugated nanoparticles prevent retina damage induced by oxidative stress.Cellular and molecular life sciences : CMLS · 2018Article
- Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells.Stem cells international · 2017Article
- Iron oxide nanoparticles for neuronal cell applications: uptake study and magnetic manipulations.Journal of nanobiotechnology · 2016Article
- Application of iron oxide anoparticles in neuronal tissue engineering.Neural regeneration research · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basic fibroblast growth factor (FGF-2). Comparative stability studies of free versus conjugated factors revealed that the conjugated neurotrophic factors were significantly more stable in tissue cultures and in medium at 37°C. The biological effects of free versus conjugated neurotrophic factors were examined on organotypic dorsal root ganglion (DRG) cultures performed in NVR-Gel, composed mainly of hyaluronic acid and laminin. Results revealed that the conjugated neurotrophic factors enhanced early nerve fiber sprouting compared to the corresponding free factors. The most meaningful result was that conjugated-GDNF, accelerated the onset and progression of myelin significantly earlier than the free GDNF and the other free and conjugated factors. This is probably due to the beneficial and long-acting effect that the stabilized conjugated-GDNF had on neurons and Schwann cells. These conclusive results make NVR-Gel enriched with conjugated-GDNF, a desirable scaffold for the reconstruction of severed peripheral nerve.
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