ReviewFrontiers in public health2014
Current Perspectives on Viable but Non-Culturable (VBNC) Pathogenic Bacteria.
Review in Frontiers in public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
181 citing papers in PubMed, 2 syntheses or guidelines pooled it, 440 citations in OpenAlex.
- AI-Enabled Imaging for Pathogen Detection Under Stress Conditions: A Systematic Review.Comprehensive reviews in food science and food safety · 2026Pooled it
- A systematic review of chlorine-based surface disinfection efficacy to inform recommendations for low-resource outbreak settings.American journal of infection control · 2021Pooled it
- Storage Survival and Thermal Inactivation ofFoods (Basel, Switzerland) · 2026Article
- Conditional superiorities and unaddressed bottlenecks: a critical review of artificial intelligence for waterborne microbial detection.Applied microbiology and biotechnology · 2026Review
- Separating pathogens from drinking water and food using magnetic nanomaterials: opportunities and challenges.Journal of nanobiotechnology · 2026Review
- Post-Inoculation Drying and Storage Effects on HAB Viability and Nutrient Retention in Biochar.Biotech (Basel (Switzerland)) · 2026Article
- Improving Microbiological Monitoring of Hospital Surfaces: Loop-Mediated Isothermal Amplification (LAMP) as a New Approach for Rapid Nosocomial Pathogens Detection.International journal of environmental research and public health · 2026Article
- Food-borne bacterial pathogens: emerging approaches in detection and prevention.Archives of microbiology · 2026Review
- Probiotic Viability Reconsidered: Integrating VBNC Resuscitation and Culture-Independent Methods for Accurate Probiotic Enumeration.Microorganisms · 2025Review
- Bacteriophage T4 propagation in E.coli exposed to severe substrate limitation.Virology journal · 2025Article
- Presence of Potentially Infectious Human Enteric Viruses and Antibiotic Resistance Genes in Mussels from the Campania Region, Italy: Implications for Consumer's Safety.Food and environmental virology · 2025Article
- Nanoplastics-mediated physiologic and genomic responses in pathogenic Escherichia coli O157:H7.Journal of nanobiotechnology · 2025Article
- Article
- High incidence of multidrug-resistant organisms and modifiable risk factors associated with surgical site infections: a cohort study in a tertiary medical center in Kuala Lumpur, Malaysia from 2020 to 2023.Antimicrobial resistance and infection control · 2025Article
- Article
- Environmental desiccation stress induces viable but non culturable state in Neisseria meningitidis.Archives of microbiology · 2025Article
- Assessing the physiological properties of baker's yeast based on single-cell Raman spectrum technology.Synthetic and systems biotechnology · 2025Article
- Optimization of the viability PCR for accurate detection of Staphylococcus aureus in food samples.PloS one · 2025Article
- Application of Metagenomic Next-Generation Sequencing in HIV-Infected Patients with Bloodstream Infections.Infection and drug resistance · 2025Article
- Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy.Frontiers in cellular and infection microbiology · 2025Review
121 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under stress conditions, many species of bacteria enter into starvation mode of metabolism or a physiologically viable but non-culturable (VBNC) state. Several human pathogenic bacteria have been reported to enter into the VBNC state under these conditions. The pathogenic VBNC bacteria cannot be grown using conventional culture media, although they continue to retain their viability and express their virulence. Though there have been debates on the VBNC concept in the past, several molecular studies have shown that not only can the VBNC state be induced under in vitro conditions but also that resuscitation from this state is possible under appropriate conditions. The most notable advance in resuscitating VBNC bacteria is the discovery of resuscitation-promoting factor (Rpf), which is a bacterial cytokines found in both Gram-positive and Gram-negative organisms. VBNC state is a survival strategy adopted by the bacteria, which has important implication in several fields, including environmental monitoring, food technology, and infectious disease management; and hence it is important to investigate the association of bacterial pathogens under VBNC state and the water/foodborne outbreaks. In this review, we describe various aspects of VBNC bacteria, which include their proteomic and genetic profiles under the VBNC state, conditions of resuscitation, methods of detection, antibiotic resistance, and observations on Rpf.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.