Evidence map›Paper›PMID 25133066›Full record

ArticleJournal of clinical & cellular immunology2013

Microbial Infection and Rheumatoid Arthritis.

Song Li, Yangsheng Yu, Yinshi Yue, Zhixin Zhang, Kaihong Su

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical & cellular immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 4 syntheses or guidelines pooled it, 135 citations in OpenAlex.

  1. Pooled it
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  9. Journal of oral microbiology · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Song LiDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yangsheng YuDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Yinshi YueDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Zhixin ZhangDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kaihong SuDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA ; The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA ; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
University of Nebraska Medical Center · US

Funding

Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLER01AI076475 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, ZHIXIN · 2008 to 2012
$1.6M
Novel Neutrophil Autoantigens in Systemic Lupus ErythematosusR01AR059351 · NIAMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SU, KAIHONG · 2011 to 2015
$1.5M
Molecular Regulation of VH Gene Replacement in Human Immature B CellsR01AI074948 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, ZHIXIN · 2008 to 2012
$1.5M
Contribution of VH Replacement to B Cell Anti-HIV Immune ResponseR21AI073174 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ZHANG, ZHIXIN · 2007 to 2008
$363k
Molecular Basis of Human VH Gene ReplacementK01AR048592 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, ZHIXIN · 2002 to 2006
$351k
NIAID NIH HHS R01 AI074948NIAID NIH HHS R01 AI076475NIAID NIH HHS R21 AI073174NIAMS NIH HHS K01 AR048592NIAMS NIH HHS R01 AR059351
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a complex autoimmune disease affecting 1-2% of general worldwide population. The etiopathogenesis of RA involves the interplay of multiple genetic risk factors and environmental triggers. Microbial infections are believed to play an important role in the initiation and perpetuation of RA. Recent clinical studies have shown the association of microbial infections with RA. Accumulated studies using animal models have also found that microbial infections can induce and/or exaggerate the symptoms of experimental arthritis. In this review, we have identified the most common microbial infections associated with RA in the literature and summarized the current evidence supporting their pathogenic role in RA. We also discussed the potential mechanisms whereby infection may promote the development of RA, such as generation of neo-autoantigens, induction of loss of tolerance by molecular mimicry, and bystander activation of the immune system.

Indexed as

EtiopathogenesisInfectionMicrobesRheumatoid arthritis

Identifiers

PMID25133066
PMCPMC4131749
OpenAlexW2141561944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.