ReviewWorld journal of gastrointestinal pharmacology and therapeutics2014
Pharmacological therapy of feed intolerance in the critically ills.
Review in World journal of gastrointestinal pharmacology and therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- ACG Clinical Guideline: Nutrition Therapy in the Adult Hospitalized Patient.The American journal of gastroenterology · 2016Guideline
- Mosapride versus Metoclopramide in Critically Ill Patients with Enteral Feeding Intolerance: A Randomized, Double-Blinded Comparison.Drug design, development and therapy · 2026Trial
- Selected Serious Adverse Events in a Cohort of Adult ICU Patients: Protocol for a Sub-Study of the PATIENCE Cohort.Acta anaesthesiologica Scandinavica · 2025Article
- Preferences on the Use of Prokinetic Agents in Adult Intensive Care Unit Patients-An International Survey.Acta anaesthesiologica Scandinavica · 2025Article
- Use of erythromycin and metoclopramide in hospitalized dogs: a multicenter historical cohort study.Frontiers in veterinary science · 2025Article
- The incidence and risk factors of gastrointestinal dysfunction during enteral nutrition in mechanically ventilated critically ill patients.Nursing open · 2024Observational
- Pediatric Tui Na for Feeding Intolerance in Premature Infants: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2023Article
- Therapeutic Efficacy of Nasoenteric Tube Feeding in Children Needing Enteral Nutrition.Frontiers in pediatrics · 2021Article
- The frequency, risk factors, and complications of gastrointestinal dysfunction during enteral nutrition in critically ill patients.Therapeutics and clinical risk management · 2018Article
- Studying the effect of abdominal massage on the gastric residual volume in patients hospitalized in intensive care units.Journal of intensive care · 2018Article
- [Enteral nutrition therapy in critical care : Current knowledge, controversies, and practical implementation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feed intolerance in the setting of critical illness is associated with higher morbidity and mortality, and thus requires promptly and effective treatment. Prokinetic agents are currently considered as the first-line therapy given issues relating to parenteral nutrition and post-pyloric placement. Currently, the agents of choice are erythromycin and metoclopramide, either alone or in combination, which are highly effective with relatively low incidence of cardiac, hemodynamic or neurological adverse effects. Diarrhea, however, can occur in up to 49% of patients who are treated with the dual prokinetic therapy, which is not associated with Clostridium difficile infection and settled soon after the cessation of the drugs. Hence, the use of prokinetic therapy over a long period or for prophylactic purpose must be avoided, and the indication for ongoing use of the drug(s) must be reviewed frequently. Second line therapy, such as total parenteral nutrition and post-pyloric feeding, must be considered once adverse effects relating the prokinetic therapy develop.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.