ArticleJapanese journal of cancer research : Gann1989
Inhibition of tumor cell invasion by ubenimex (bestatin) in vitro.
Article in Japanese journal of cancer research : Gann, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 86 citations in OpenAlex.
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- The Role of the Ectopeptidase APN/CD13 in Cancer.Biomedicines · 2023Review
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- RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer.Cancer science · 2014Article
- Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.Cancer science · 2014Article
- Asymmetric synthesis of anti-β-amino-α-hydroxy esters via dynamic kinetic resolution of β-amino-α-keto esters.Organic letters · 2013Article
- Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis.ACS medicinal chemistry letters · 2012Article
- Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.BMC biochemistry · 2007Article
- Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.Cancer science · 2004Article
- Inhibitory effect of antisense aminopeptidase N (APN/CD13) cDNA transfection on the invasive potential of osteosarcoma cells.Clinical & experimental metastasis · 2003Article
- Inhibition by vasoactive intestinal polypeptide (VIP) of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver.Clinical & experimental metastasis · 1999Article
- Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.Clinical & experimental metastasis · 1998Article
- Inhibition of tumor cell haptotaxis by sodium D-glucaro-delta-lactam (ND2001).Japanese journal of cancer research : Gann · 1995Article
- Human melanoma invasion and metastasis enhancement by high expression of aminopeptidase N/CD13.Clinical & experimental metastasis · 1995Article
- Ubenimex activates the E-cadherin-mediated adhesion of a breast cancer cell line YMB-S.Japanese journal of cancer research : Gann · 1995Article
- Inhibition of pulmonary metastases and tumor cell invasion in experimental tumors by sodium D-glucaro-delta-lactam (ND2001).Japanese journal of cancer research : Gann · 1995Article
- Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.Japanese journal of cancer research : Gann · 1994Article
- Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation.International journal of cancer · 1993Article
- Antimetastatic effect by anti-adhesion therapy with cell-adhesive peptide of fibronectin in combination with anticancer drugs.Japanese journal of cancer research : Gann · 1993Article
- Differences in chemotaxis to fibronectin in weakly and highly metastatic tumor cells.Japanese journal of cancer research : Gann · 1992Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the effect of the immunomodulator ubenimex (bestatin) on tumor cell invasion of reconstituted basement membrane (Matrigel). The invasion of B16-BL6 melanoma cells and Lewis lung carcinoma (3LL) cells into Matrigel-coated filters was inhibited by the presence of bestatin in a concentration-dependent manner. The pretreatment of either tumor cells or Matrigel with bestatin, however, had little effect on the invasion of tumor cells. Since bestatin was found to inhibit amino-peptidase in addition to its immunomodulating activities, the inhibition of tumor invasion by bestatin is likely to be associated with the action as an enzyme inhibitor. Other aminopeptidase inhibitors, arphamenine B and amastatin A, could also inhibit tumor cell invasion into Matrigel. Bestatin inhibited hydrolyzing activities towards substrates of aminopeptidases in B16-BL6 melanoma cells. However, bestatin did not have any effect on the haptotactic migration and adhesion of tumor cells to the substrates. These results indicated that bestatin may inhibit tumor cell invasion through a mechanism involving its inhibitory action on aminopeptidases in tumor cells.
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