ArticleWorld journal of gastrointestinal pathophysiology2014
Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.
Article in World journal of gastrointestinal pathophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- PSCA rs2294008 Polymorphism with Increased Risk of Cancer.PloS one · 2015Pooled it
- Clinical and pathological study of mutL homolog 1-deficient gastric cancer and the search for background gene expression changes.Surgery today · 2026Article
- Prognostic value of LODDS in late-onset gastric adenocarcinoma: analysis of SEER, TCGA, and external multicenter cohorts.Frontiers in oncology · 2025Article
- Article
- Factors associated with precancerous stomach lesions and progresion: A 7-year multi-center prospective cohort study on the low incidence of gastric cancer in central Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Environmental and Genetic Risk Factors for Gastric Cancer.Cancer treatment and research · 2024Review
- Environmental and genetic risk factors for gastric cancer.Journal of surgical oncology · 2022Review
- Review
- Aldehyde Dehydrogenase 1 in Gastric Cancer.Journal of oncology · 2022Review
- Role of Helicobacter pylori infection in the manifestation of old age-related diseases.Molecular genetics & genomic medicine · 2020Review
- Expression of ALDH1A1 and CD133 is associated with the prognosis and effect of different chemotherapeutic regimens in gastric cancer.Oncology letters · 2019Article
- Immunohistochemical Analysis of LGR5 and TROY Expression in Gastric Carcinogenesis Demonstrates an Inverse TrendIranian biomedical journal · 2019Article
- Impact of age on stage-specific mortality in patients with gastric cancer: A long-term prospective cohort study.PloS one · 2019Article
- Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells.Cancer communications (London, England) · 2018Article
- Regulation of Gastric Lgr5+ve Cell Homeostasis by Bone Morphogenetic Protein (BMP) Signaling and Inflammatory Stimuli.Cellular and molecular gastroenterology and hepatology · 2018Article
- Regulation of Gastric Metaplasia, Dysplasia, and Neoplasia by Bone Morphogenetic Protein Signaling.Cellular and molecular gastroenterology and hepatology · 2017Review
- Dopamine receptor D2 is correlated with gastric cancer prognosis.Oncology letters · 2017Article
- Network analysis of common genes related to esophageal, gastric, and colon cancers.Gastroenterology and hepatology from bed to bench · 2017Article
- Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker.Journal of cancer prevention · 2016Article
- Correlation between FOXP3 expression and gastric cancer.Oncology letters · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimTo demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells (CSCs) of gastric mucosa in an animal model.
methodsIn this study we investigated the effects of aging and Helicobacter pylori (H. pylori) inflammation as a model for inflammation induced carcinogenesis in human and rat gastric mucosa samples. In aging studies, we compared 4-mo old (young) with 22 mo (aged) old Fischer-344 rats. For human studies, gastric biopsies and resection specimens representing normal mucosa or different stages of H. pylori gastritis and gastric adenocarcinomas were used for determining the expression of stem cell markers CD166, ALDH1 and LGR5. In addition we performed immunofluorescent double labeling for B-catenin and Lgr5 in both rat and human gastric tissues to examine the status of Wnt signaling in these cells.
resultsCSC markers ALDH1, LGR5, and CD166 were expressed in very low levels in normal human gastric mucosa or young rat gastric mucosa. In contrast, level of expression for all three markers significantly increased in H. pylori gastritis and gastric adenocarcinomas as well as in normal gastric mucosa in aged rats. We also observed cytoplasmic B-catenin staining in both aged rat and human H. pylori inflamed gastric mucosa, which were found to be colocalized with Lgr5 immunoreactive cells. The increased number of ALDH1, CD166 and LGR5 positive cells in H. pylori gastritis indicates that increased number of stem-like cells in gastric mucosa is an early event, and may constitute an important step in the progression to neoplasia.
conclusionOur observation of the age-related increase in cancer stem/stem-like cells in the gastric mucosa may explain the increased incidence of gastric cancer during aging. Combination of aging and H. pylori infection may have additive effects in progression to neoplasia.
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