Evidence map›Paper›PMID 25132995›Full record

ArticleInternational journal of breast cancer2014

Similarity of fibroglandular breast tissue content measured from magnetic resonance and mammographic images and by a mathematical algorithm.

Fatima Nayeem, Hyunsu Ju, Donald G Brunder, Manubai Nagamani, Karl E Anderson, Tuenchit Khamapirad, Lee-Jane W Lu

Abstract read
In one paragraph

Article in International journal of breast cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Adiposity, breast density, and breast cancer risk: epidemiological and biological considerations.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatima NayeemDivision of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555-1109, USA.ORCID 0000-0001-7339-4934
Hyunsu JuDivision of Biostatistics, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77550-1147, USA.
Donald G BrunderDepartment of Academic Computing, The University of Texas Medical Branch, Galveston, TX 77555-1035, USA.
Manubai NagamaniDepartment of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, TX 77555, USA ; Houston Bay Area Fertility Center, 9C Professional Park Drive, Webster, TX 77598, USA.ORCID 0000-0003-0172-6498
Karl E AndersonDivision of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555-1109, USA.
Tuenchit KhamapiradDepartment of Radiology, The University of Texas Medical Branch, Galveston, TX 77555, USA ; Breast Center, The Methodist Willowbrook Hospital, Houston, TX 77070, USA.
Lee-Jane W LuDivision of Human Nutrition, Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555-1109, USA.

Funding

ZOLLINGER-ELLISON SYNDROME AND DUODONAL ULCER DISEASEM01RR000073 · NCRR · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI VOLPI, ELENA · 1985 to 2009
$31.3M
Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
Mammographic Density and Soy IsoflavonesR01CA095545 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI LU, LEE-JANE W · 2003 to 2010
$2.6M
PHYTOESTROGENS AND BREAST CANCER PREVENTIONR01CA065628 · NCI · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI LU, LEE-JANE W · 1996 to 1998
–
NCATS NIH HHS UL1 TR000071NCI NIH HHS R01 CA095545NCRR NIH HHS M01 RR000073NIEHS NIH HHS P30 ES006676
6 · The paper itself

Abstract

Women with high breast density (BD) have a 4- to 6-fold greater risk for breast cancer than women with low BD. We found that BD can be easily computed from a mathematical algorithm using routine mammographic imaging data or by a curve-fitting algorithm using fat and nonfat suppression magnetic resonance imaging (MRI) data. These BD measures in a strictly defined group of premenopausal women providing both mammographic and breast MRI images were predicted as well by the same set of strong predictor variables as were measures from a published laborious histogram segmentation method and a full field digital mammographic unit in multivariate regression models. We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. Our results show that methods of breast imaging and modalities for estimating the amount of glandular tissue have no effects on the strength of these predictors of BD. Thus, the more convenient mathematical algorithm and the safer MRI protocols may facilitate prospective measurements of BD.

Identifiers

PMID25132995
PMCPMC4123610

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.