Evidence map›Paper›PMID 25132967›Full record

ArticleMolecular and cellular therapies2014

Directed cardiomyogenesis of autologous human induced pluripotent stem cells recruited to infarcted myocardium with bioengineered antibodies.

Marek Malecki, Emily Putzer, Chelsea Sabo, Afsoon Foorohar, Carol Quach, Chris Stampe, Michael Beauchaine, Raf Malecki, Xenia Tombokan, Mark Anderson

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular and cellular therapies, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Marek MaleckiPhoenix Biomolecular Engineering Foundation, San Francisco, CA, USA ; National Magnetic Resonance Facility, National Institutes of Health, Madison, WI, USA ; University of Wisconsin, Madison, WI, USA.
Emily PutzerUniversity of Wisconsin, Madison, WI, USA ; American Youth Center, Washington, DC, USA.
Chelsea SaboUniversity of Wisconsin, Madison, WI, USA ; University of Sheffield, Sheffield, UK, EU.
Afsoon FooroharPhoenix Biomolecular Engineering Foundation, San Francisco, CA, USA ; Western University, Lebanon, OR, USA.
Carol QuachPhoenix Biomolecular Engineering Foundation, San Francisco, CA, USA ; Western University, Pomona, CA, USA.
Chris StampeUniversity of Minnesota, Minneapolis, MN, USA.
Michael BeauchaineAXS Bruker, Madison, WI, USA.
Raf MaleckiSan Francisco State University, San Francisco, CA, USA.
Xenia TombokanBioSpin Bruker, Woodlands, TX, USA.
Mark AndersonNational Magnetic Resonance Facility, National Institutes of Health, Madison, WI, USA ; University of Wisconsin, Madison, WI, USA.
Bruker (United States) · USNational Institutes of Health · USWestern University of Health Sciences · USSan Francisco State University · USUniversity of Minnesota · USUniversity of Sheffield · GBUniversity of Wisconsin–Madison · US

Funding

WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 1985 to 2011
$13.0M
XENOPUS OOCYTE NUCLEAR ENVELOPE STRUCTUREP41RR000570 · NCRR · UNIVERSITY OF WISCONSIN MADISON · 1985 to 1998
–
NCRR NIH HHS P41 RR000570NCRR NIH HHS P41 RR002301
6 · The paper itself

Abstract

objectiveMyocardial infarctions constitute a major factor contributing to non-natural mortality world-wide. Clinical trials of myocardial regenerative therapy, currently pursued by cardiac surgeons, involve administration of stem cells into the hearts of patients suffering from myocardial infarctions. Unfortunately, surgical acquisition of these cells from bone marrow or heart is traumatic, retention of these cells to sites of therapeutic interventions is low, and directed differentiation of these cells

methodsPeripheral blood was drawn from six patients scheduled for heart transplants. Mononuclear cells were isolated and reprogrammed, with plasmids carrying six genes (

resultsThe patients' mononuclear cells were efficiently reprogrammed into the ahiPSCs. These ahiPSCs were administered to infarcted myocardium in

conclusionsThe proof of concept has been attained

Indexed as

autologous human induced pluripotent stem cellcardiac regenerationheterospecific, tetravalent antibodiesMyocardial infarctionpluripotent stem cell tumorigenicityrecruitment and retention of stem cellsstage specific embryonic antigenstem cell therapytumor related antigen

Identifiers

PMID25132967
PMCPMC4131312
OpenAlexW2118236227

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.