Evidence map›Paper›PMID 25132274›Full record

ArticleActa biomaterialia2015

Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells.

Chunmei Li, Tingting Luo, Zhaozhu Zheng, Amanda R Murphy, Xiaoqin Wang, David L Kaplan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Recent Advances and Disputes About Curcumin in Retinal Diseases.Clinical ophthalmology (Auckland, N.Z.) · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. DNA preservation in silk.Biomaterials science · 2017
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Chunmei LiNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Tingting LuoNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.
Zhaozhu ZhengNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China.
Amanda R MurphyDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA; Department of Chemistry, Western Washington University, Bellingham, WA 98225, USA.
Xiaoqin WangNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: wangxiaoqin@suda.edu.cn.
David L KaplanNational Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China; Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.
Soochow University · CNTufts University · USWestern Washington University · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Training in Education and Critical Research SkillsK12GM074869 · NIGMS · TUFTS UNIVERSITY BOSTON · PI MOORE, CLAIRE L · 2006 to 2017
$8.5M
Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
NIAMS NIH HHS AR005593NIAMS NIH HHS AR061988NIAMS NIH HHS R01 AR061988NIBIB NIH HHS P41 EB002520NIGMS NIH HHS K12 GM074869
6 · The paper itself

Abstract

Curcumin, a natural phenolic compound derived from the plant Curcuma longa, was physically entrapped and stabilized in silk hydrogel films, and its influence on human bone marrow-derived mesenchymal stem cells (hBMSC) was assessed related to adipogenic differentiation. The presence of curcumin significantly reduced the silk gelation time and changed the porous morphology of gel matrix, but did not change the formation of the silk beta-sheet structure. Based on spectrofluorimetric analysis, curcumin most likely interacted with hydrophobic residues in silk, interacting with the beta-sheet domains formed in the hydrogels. The antioxidant activity of silk film-associated curcumin remained functional over at least one month in both the dry and hydrated state. Negligible curcumin was released from silk hydrogel films over 48 h incubation in aqueous solution. For hBMSC cultured on silk films containing more than 0.25 mg ml(-1) curcumin, cell proliferation was inhibited, while adipogenesis was significantly promoted based on transcripts as well as Oil Red O staining. When hBMSC were cultured in media containing free curcumin, both proliferation and adipogenesis of hBMSC were inhibited when curcumin concentrations exceeded 5 μM, which is more than 1000 times higher than the level of curcumin released from the films in aqueous solution. Thus, silk film-associated curcumin exhibited different effects on hBMSC proliferation and differentiation compared with curcumin in solution.

Indexed as

AdipocytesAdipogenesisBiocompatible MaterialsBone Marrow CellsCell DifferentiationCells, CulturedCurcuminHumansMaterials TestingMesenchymal Stem CellsSilkTissue EngineeringBiocompatible MaterialsCurcuminSilkAdipogenesisCurcuminDifferentiationMesenchymal stem cellsSilk fibroin

Identifiers

PMID25132274
PMCPMC4256115
OpenAlexW1972675892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.