Evidence map›Paper›PMID 25132206›Full record

Trial reportPsycho-oncology2015

Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors.

Shelley A Johns, Linda F Brown, Kathleen Beck-Coon, Patrick O Monahan, Yan Tong, Kurt Kroenke

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02611544 (Investigation of Three Approaches to Address Fear of Recurrence Among Breast Cancer Survivors), which is not on this map. Cited by 68 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 17 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02611544 nacompletednot on this map

Investigation of Three Approaches to Address Fear of Recurrence Among Breast Cancer Survivors: A Randomized Clinical Pilot Trial

TypeinterventionalSponsorIndiana UniversityRan2015 to 2016Enrolled91ConditionsBreast Neoplasms, Breast Cancer, Breast Carcinoma, Malignant Neoplasm of BreastArmsAcceptance and Commitment Therapy, Survivorship Education, Enhanced Usual Care
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 17 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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  13. The effectiveness of mindfulness-based interventions among cancer patients and survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
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  16. Mindfulness-based stress reduction for women diagnosed with breast cancer.The Cochrane database of systematic reviews · 2019
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Shelley A JohnsIndiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0001-5730-1822
Linda F BrownIndiana University School of Medicine, Indianapolis, IN, USA.
Kathleen Beck-CoonIndiana University School of Nursing, Indianapolis, IN, USA.
Patrick O MonahanIndiana University School of Medicine, Indianapolis, IN, USA.
Yan TongIndiana University School of Medicine, Indianapolis, IN, USA.
Kurt KroenkeIndiana University School of Medicine, Indianapolis, IN, USA.
Indiana University School of MedicineRegenstrief Institute · USIndiana University – Purdue University Indianapolis · US

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Training in Research for Behavioral Oncology and Cancer Control ProgramR25CA117865 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2006 to 2015
$4.1M
Research and Training for Behavioral Oncology InterventionsK05CA175048 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHAMPION, VICTORIA LEE · 2014 to 2018
$484k
NCATS NIH HHS UL1 TR001108NCI NIH HHS K05 CA175048NCI NIH HHS R25 CA117865NCI NIH HHS R25 CA 117865-01A11
6 · The paper itself

Abstract

objectiveCancer-related fatigue (CRF) is one of the most common, persistent, and disabling symptoms associated with cancer and its treatment. Evidence-based treatments that are acceptable to patients are critically needed. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for CRF and related symptoms.

methodA sample of 35 cancer survivors with clinically significant CRF was randomly assigned to a 7-week MBSR-based intervention or wait-list control group. The intervention group received training in mindfulness meditation, yoga, and self-regulatory responses to stress. Fatigue interference (primary outcome) and a variety of secondary outcomes (e.g., fatigue severity, vitality, disability, depression, anxiety, and sleep disturbance) were assessed at baseline, post-intervention, and 1-month follow-up. Bonferroni correction was employed to account for multiple comparisons. Controls received the intervention after the 1-month follow-up. Participants in both groups were followed for 6 months after completing their respective MBSR courses to assess maintenance of effects.

resultsCompared to controls, the MBSR group reported large post-intervention reductions as assessed by effect sizes (d) in the primary outcome, fatigue interference (d = -1.43, p < 0.001), along with fatigue severity (d = -1.55, p < 0.001), vitality (d = 1.29, p < 0.001), depression (d = -1.30, p < 0.001), and sleep disturbance (d = -0.74, p = 0.001). Results were maintained or strengthened at 1-month follow-up, the point at which significant improvements in disability (d = -1.22, p < 0.002) and anxiety (d = -0.98, p = 0.002) occurred. Improvements in all outcomes were maintained 6 months after completing the course. MBSR adherence was high, with 90% attendance across groups and high rates of participant-reported home practice of mindfulness.

conclusionsMindfulness-based stress reduction is a promising treatment for CRF and associated symptoms.

Indexed as

MindfulnessAgedAnxietyDepressionFatigueFemaleHumansMaleMeditationMiddle AgedNeoplasmsPersons with DisabilitiesPilot ProjectsSample SizeSelection BiasSeverity of Illness Indexcancercancer-related fatigueMBSRmeditationmindfulnessoncology

Identifiers

PMID25132206
PMCPMC4331267
OpenAlexW1575958965

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.