ArticleJMIR research protocols2014
The Nurse-Based Age Independent Intervention to Limit Evolution of Disease After Acute Coronary Syndrome (NAILED ACS) Risk Factor Trial: Protocol for a Randomized Controlled Trial.
Article in JMIR research protocols, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Trial
- Nurse-led, telephone-based follow-up after acute coronary syndrome yields improved risk factors after 36 months: the randomized controlled NAILED-ACS trial.Scientific reports · 2021Trial
- Statin treatment after acute coronary syndrome: Adherence and reasons for non-adherence in a randomized controlled intervention trial.Scientific reports · 2019Trial
- Trial
- Implementation of a new guideline in cardiovascular secondary preventive care: subanalysis of a randomized controlled trial.BMC cardiovascular disorders · 2016 · on this mapTrial
- Trial
- Cardiovascular secondary prevention in high-risk patients: a randomized controlled trial sub-study.BMC cardiovascular disorders · 2015Trial
- Long-term risk of major adverse cardiovascular events following ischemic stroke or TIA.Scientific reports · 2023Article
- Incidence and predictors of cardiovascular outcomes after acute coronary syndrome in a population-based cohort study.Scientific reports · 2023Article
- Epidemiological Characterization of a Directed and Weighted Disease Network Using Data From a Cohort of One Million Patients: Network Analysis.Journal of medical Internet research · 2020Article
- Low use of statins for secondary prevention in primary care: a survey in a northern Swedish population.BMC family practice · 2016Article
- Pre-hospital delay in patients with first time myocardial infarction: an observational study in a northern Swedish population.BMC cardiovascular disorders · 2016Observational
- HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and Methods.JMIR research protocols · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecondary prevention after acute coronary syndrome (ACS) is essential to reduce morbidity and mortality, but related studies have been fairly small or performed as clinical trials with non-representative patient selection. Long-term follow-up data are also minimal. A nurse-led follow-up for risk factor improvement may be effective, but the evidence is limited.
objectiveThe aims of this study are to perform an adequately sized, nurse-led, long-term secondary preventive follow-up with inclusion of an unselected population of ACS patients. The focus will be on lipid and blood pressure control as well as tobacco use and physical activity.
methodsThe study will consist of a randomized, controlled, long-term, population-based trial with two parallel groups. Patients will be included during the initial hospital stay. Important outcome variables are total cholesterol, low-density lipoprotein (LDL) cholesterol, and sitting systolic and diastolic blood pressure. Outcomes will be measured after 12, 24, and 36 months of follow-up. Trained nurses will manage the intervention group with the aim of achieving set treatment goals as soon as possible. The control group will receive usual care. At least 250 patients will be included in each group to reliably detect a difference in mean LDL of 0.5 mmol/L and in mean systolic blood pressure of 5 mmHg.
resultsThe study is ongoing and recruitment of participants will continue until December 31, 2014.
conclusionsThis study will test the hypothesis that a nurse-led, long-term follow-up after an ACS with a focus on achieving treatment goals as soon as possible is an effective secondary preventive method. If proven effective, this method could be implemented in general practice at a low cost.
trial registrationInternational Standard Randomized Controlled Trial Number (ISRCTN): 96595458; http://www.controlled-trials.com/ISRCTN96595458 (Archived by WebCite at http://www.webcitation.org/6RlyhYTYK).
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