SynthesisContemporary clinical trials2014
Strategies addressing barriers to clinical trial enrollment of underrepresented populations: a systematic review.
Synthesis in Contemporary clinical trials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
170 citing papers in PubMed, 6 syntheses or guidelines pooled it, 299 citations in OpenAlex.
- Strategies to increase participant diversity in pediatric research: a systematic review.Pediatric research · 2026Pooled it
- Strategies to reach, involve, and maintain underserved populations in health intervention research: a systematic review of reviews.International journal for equity in health · 2026Pooled it
- Cultural competency and inclusion training for healthcare professionals: a systematic review to inform training for health research professionals.BMC health services research · 2026Pooled it
- Recruitment, retention and reporting of variables related to ethnic diversity in randomised controlled trials: an umbrella review.BMJ open · 2024Pooled it
- Improving African American women's engagement in clinical research: A systematic review of barriers to participation in clinical trials.Journal of the National Medical Association · 2022Pooled it
- Comparison of Response to Definitive Radiotherapy for Localized Prostate Cancer in Black and White Men: A Meta-analysis.JAMA network open · 2021Pooled it
- Incorporating health literacy principles into the adaptation of a methods motivational interviewing approach for enrolling black adults in a pilot randomized trial.Scientific reports · 2025Trial
- Resource Requirements for Participant Enrollment From a University Health System and a Federally Qualified Health Center Network in a Mobile Health Study: The myBPmyLife Trial.Journal of the American Heart Association · 2024Trial
- Trial
- Recruitment in a research study via chatbot versus telephone outreach: a randomized trial at a minority-serving institution.Journal of the American Medical Informatics Association : JAMIA · 2021Trial
- Using increased trust in medical researchers to increase minority recruitment: The RECRUIT cluster randomized clinical trial.Contemporary clinical trials · 2021Trial
- Recruitment and enrollment of participants in an online diabetes self-management intervention in a virtual environment.Contemporary clinical trials · 2021Trial
- Engaging limited English proficient and ethnically diverse low-income women in health research: A randomized trial of a patient navigator intervention.Patient education and counseling · 2019Trial
- Cancer-Specific Stress and Trajectories of Psychological and Physical Functioning in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
- Design, methods, and baseline characteristics of the Kids' Health Insurance by Educating Lots of Parents (Kids' HELP) trial: a randomized, controlled trial of the effectiveness of parent mentors in insuring uninsured minority children.Contemporary clinical trials · 2015Trial
- What can we learn from a failed trial: insight into non-participation in a chat-based intervention trial for adolescents with psychosocial problems.BMC research notes · 2014Trial
- Maternal Prenatal Depressive Symptoms and Fetal Amygdala-Cerebellum Functional Connectivity.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- "It's Like Disrupting Internally:" a Qualitative Study of Opportunities and Limitations to Promote Diversity in Participant Recruitment in Health Research.Journal of racial and ethnic health disparities · 2026Article
- Diverse Recruitment for Clinical Trials Using Three Diversity-Enhancing Interventions: Qualitative Study.JMIR formative research · 2026Article
- Limited inclusion in clinical trials and access to poly (ADP-ribose) polymerase inhibitors in racial and ethnic minority patients with cancer: a narrative review.The oncologist · 2026Review
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundUnderrepresentation of racial and ethnic minorities in clinical trials remains a reality while they have disproportionately higher rates of health disparities.
objectiveThe purpose of this study was to identify successful community-engaged interventions that included health care providers as a key strategy in addressing barriers to clinical trial enrollment of underrepresented patients.
designA systematic review of the literature on interventions addressing enrollment barriers to clinical trials for racial and ethnic minorities was performed in Ovid MEDLINE, EBSCO Megafile, and EBSCO CINAHL. The systematic review identified 360 studies, and 20 were selected using the inclusion criteria. An iterative process extracted information from the eligible studies.
resultsThe 20 selected studies were analyzed and then grouped by first author, nature of the clinical research initiative, priority populations, key strategies, and study outcomes. Nine of the studies addressed cancer clinical trials and 11 related to chronic medical conditions, including diabetes, hypertension management, and chronic kidney disease. The key strategies employed were categorized according to their presumed impact on barriers incurred at distinct steps in study recruitment: clinical trial awareness, opportunity to participate, and acceptance of enrollment. The strategies were further categorized by whether they would address barriers associated with minority perceptions of the research process and barriers related to how studies were designed and implemented.
conclusionMultiple and flexible strategies targeting providers and participants at provider sites and within communities might be needed to enroll underrepresented populations into clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.