Evidence map›Paper›PMID 25131777›Full record

ArticleExperimental parasitology2014

One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.

Geetha Kannan, Emese Prandovszky, Curtis B Steinfeldt, Kristin L Gressitt, ChunXia Yang, Robert H Yolken, Emily G Severance, Lorraine Jones-Brando, Mikhail V Pletnikov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental parasitology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. mBio · 2025
    Article
  2. Foods (Basel, Switzerland) · 2022
    Review
  3. Article
  4. Article
  5. Review
  6. A NewScientifica · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Geetha KannanDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: gkannan1@jhmi.edu.
Emese PrandovszkyStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Curtis B SteinfeldtStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Kristin L GressittStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
ChunXia YangDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Robert H YolkenStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Emily G SeveranceStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Lorraine Jones-BrandoStanley Division of Developmental Neurovirology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
Mikhail V PletnikovDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Molecular and Comparative Pathobiology, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 600 North Wolfe Street, Baltimore, MD 21287, USA.

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
NIGMS NIH HHS T32 GM008752NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728
6 · The paper itself

Abstract

We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection.

Indexed as

Ultraviolet RaysAnimalsAntibodies, ProtozoanBrainCell MembraneCytokinesImmunoglobulin GKineticsMaleMiceMice, Inbred BALB CRabbitsReal-Time Polymerase Chain ReactionRNA, ProtozoanRNA, Ribosomal, 5STime FactorsAntibodies, ProtozoanCytokinesImmunoglobulin GRNA, ProtozoanRNA, Ribosomal, 5SAnimal modelsBehaviorCystsImmune responseInactivationToxoplasma

Identifiers

PMID25131777
PMCPMC4435842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.