ArticleCurrent biology : CB2014
Self-generated movements with "unexpected" sensory consequences.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- Longitudinal tracking of neuronal activity from the same cells in the developing brain using Track2p.eLife · 2025Article
- Inducible NMDA receptor knockdown reveals a maintenance phase in dendritic refinement of barrel cortex neurons.iScience · 2025Article
- Sensorimotor variability distinguishes early features of cognition in toddlers with autism.iScience · 2024Article
- Activity-dependent dendrite patterning in the postnatal barrel cortex.Frontiers in neural circuits · 2024Review
- Early-life maturation of the somatosensory cortex: sensory experience and beyond.Frontiers in neural circuits · 2024Review
- Neural decoding reveals specialized kinematic tuning after an abrupt cortical transition.Cell reports · 2023Article
- Protracted development of motor cortex constrains rich interpretations of infant cognition.Trends in cognitive sciences · 2023Review
- Article
- Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse.Frontiers in neuroanatomy · 2023Article
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Review
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Review
- Sensory Coding of Limb Kinematics in Motor Cortex across a Key Developmental Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Genetic vulnerability of exposures to antenatal maternal treatments in 1- to 2-month-old infants.Infancy : the official journal of the International Society on Infant Studies · 2021Article
- Parallel and Serial Sensory Processing in Developing Primary Somatosensory and Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Reconciling competing mechanisms posited to underlie auditory verbal hallucinations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Spatiotemporal organization of myoclonic twitching in sleeping human infants.Developmental psychobiology · 2020Article
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3 authors.
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Abstract
The nervous systems of diverse species, including worms and humans, possess mechanisms for distinguishing between sensations arising from self-generated (i.e., expected) movements from those arising from other-generated (i.e., unexpected) movements [1-3]. To make this critical distinction, animals generate copies, or corollary discharges, of motor commands [4, 5]. Corollary discharge facilitates the selective gating of reafferent signals arising from self-generated movements, thereby enhancing detection of novel stimuli [6-10]. However, for a developing nervous system, such sensory gating would be counterproductive if it impedes transmission of the very activity upon which activity-dependent mechanisms depend [11]. In infant rats during active (or REM) sleep--a behavioral state that predominates in early infancy [12-16]--neural circuits within the brainstem [17, 18] trigger hundreds of thousands of myoclonic twitches each day [19]. The putative contribution of these self-generated movements to the activity-dependent development of the sensorimotor system is supported by the observation that reafference from twitching limbs reliably and substantially triggers brain activity [20-23]. In contrast, under identical testing conditions, even the most vigorous wake movements reliably fail to trigger reafferent brain activity [21-23]. One hypothesis that accounts for this paradox is that twitches, uniquely among self-generated movements, lack corollary discharge [23]. Here, we test this hypothesis in newborn rats by manipulating the degree to which self-generated movements are expected and, therefore, their presumed recruitment of corollary discharge. We show that twitches, although self-generated, are processed as if they are unexpected.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.