ReviewInternational review of neurobiology2014
Environmental alterations of epigenetics prior to the birth.
Review in International review of neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- A large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity.Scientific reports · 2022Article
- In-utero epigenetic factors are associated with early-onset myopia in young children.PloS one · 2019Article
- Pre-reproductive Parental Enriching Experiences Influence Progeny's Developmental Trajectories.Frontiers in behavioral neuroscience · 2018Review
- Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways.Molecular neurobiology · 2017Article
- From genetics to epigenetics: new insights into keloid scarring.Cell proliferation · 2017Review
- Emerging Role of Epigenetic Mechanisms in Alcohol Addiction.Alcoholism, clinical and experimental research · 2017Review
- Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome.Epigenomics · 2017Review
- Review
- Perinatal Music Therapy and Antenatal Music Classes: Principles, Mechanisms, and Benefits.The Journal of perinatal education · 2016Article
- Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico.World journal of gastroenterology · 2015Review
- The WOMED model of benign thyroid disease: Acquired magnesium deficiency due to physical and psychological stressors relates to dysfunction of oxidative phosphorylation.BBA clinical · 2015Article
- Review
- Nuclear and mitochondrial DNA alterations in newborns with prenatal exposure to cigarette smoke.International journal of environmental research and public health · 2015Review
- Perspectives on stress resilience and adolescent neurobehavioral function.Neurobiology of stress · 2015Review
- Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.Frontiers in genetics · 2015Article
- Exposure of C. elegans eggs to a glyphosate-containing herbicide leads to abnormal neuronal morphology.Neurotoxicology and teratologyArticle
- Epigenetics and Environmental Exposures in Early Neurodevelopment: Implications for Pediatric Neurological Disorders.Sage open pediatricsReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The etiology of many brain diseases remains allusive to date after intensive investigation of genomic background and symptomatology from the day of birth. Emerging evidences indicate that a third factor, epigenetics prior to the birth, can exert profound influence on the development and functioning of the brain and over many neurodevelopmental syndromes. This chapter reviews how aversive environmental exposure to parents might predispose or increase vulnerability of offspring to neurodevelopmental deficit through alteration of epigenetics. These epigenetic altering environmental factors will be discussed in the category of addictive agents, nutrition or diet, prescriptive medicine, environmental pollutant, and stress. Epigenetic alterations induced by these aversive environmental factors cover all aspects of epigenetics including DNA methylation, histone modification, noncoding RNA, and chromatin modification. Next, the mechanisms how these environmental inputs influence epigenetics will be discussed. Finally, how environmentally altered epigenetic marks affect neurodevelopment is exemplified by the alcohol-induced fetal alcohol syndrome. It is hoped that a thorough understanding of the nature of prenatal epigenetic inputs will enable researchers with a clear vision to better unravel neurodevelopmental deficit, late-onset neuropsychiatric diseases, or idiosyncratic mental disorders.
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Registered trials
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