ReviewThe Journal of comparative neurology2014
Endogenous versus exogenous markers of adult neurogenesis in canaries and other birds: advantages and disadvantages.
Review in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Vernal growth of vocal control nucleus Area X, but not HVC, precedes gonadal recrudescence in wild black-capped chickadees (Poecile atricapillus).Journal of neuroendocrinology · 2025Article
- Seasonal patterns of neurogenesis in European starlings (Sturnus vulgaris) are region- and sex-specific.Journal of neuroendocrinology · 2025Article
- Photoperiodism, testosterone and adult neurogenesis in canaries (Serinus canaria).Journal of neuroendocrinology · 2025Review
- A daily rhythm of cell proliferation in a songbird brain.Scientific reports · 2025Article
- Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice.Neural regeneration research · 2024Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries.Scientific reports · 2023Article
- Short photoperiod modulates behavior, cognition and hippocampal neurogenesis in male Japanese quail.Scientific reports · 2023Article
- Poor body condition is associated with lower hippocampal plasticity and higher gut methanogen abundance in adult laying hens from two housing systems.Scientific reports · 2022Article
- Understanding hippocampal neural plasticity in captivity: Unique contributions of spatial specialists.Learning & behavior · 2022Review
- Regional Patterning of Adult Neurogenesis in the Homing Pigeon's Brain.Frontiers in psychology · 2022Article
- Telencephalic regulation of the HPA axis in birds.Neurobiology of stress · 2021Article
- Transcriptome Analyses Reveal IL6/Stat3 Signaling Involvement in Radial Glia Proliferation After Stab Wound Injury in the Adult Zebrafish Optic Tectum.Frontiers in cell and developmental biology · 2021Article
- Article
- Emotionality modulates the impact of chronic stress on memory and neurogenesis in birds.Scientific reports · 2020Article
- New concepts in the study of the sexual differentiation and activation of reproductive behavior, a personal view.Frontiers in neuroendocrinology · 2019Review
- Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure.Metabolic brain disease · 2018Article
- Putative Adult Neurogenesis in Old World Parrots: The Congo African Grey Parrot (Frontiers in neuroanatomy · 2018Article
- High-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Functional Recovery by Enhancing Neurogenesis and Activating BDNF/TrkB Signaling in Ischemic Rats.International journal of molecular sciences · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Although the existence of newborn neurons had originally been suggested, but not broadly accepted, based on studies in adult rodent brains, the presence of an active neurogenesis process in adult homoeothermic vertebrates was first firmly established in songbirds. Adult neurogenesis was initially studied with the tritiated thymidine technique, later replaced by the injection and detection of the marker of DNA replication 5-bromo-2'-deoxyuridine (BrdU). More recently, various endogenous markers were used to identify young neurons or cycling neuronal progenitors. We review here the respective advantages and pitfalls of these different approaches in birds, with specific reference to the microtubule-associated protein, doublecortin (DCX), that has been extensively used to identify young newly born neurons in adult brains. All these techniques of course have limitations. Exogenous markers label cells replicating their DNA only during a brief period and it is difficult to select injection doses that would exhaustively label all these cells without inducing DNA damage that will also result in some form of labeling during repair. On the other hand, specificity of endogenous markers is difficult to establish due to problems related to the specificity of antibodies (these problems can be, but are not always, addressed) and more importantly because it is difficult, if not impossible, to prove that a given marker exhaustively and specifically labels a given cell population. Despite these potential limitations, these endogenous markers and DCX staining in particular clearly represent a useful approach to the detailed study of neurogenesis especially when combined with other techniques such as BrdU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.