ArticleMolecular oral microbiology2015
Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT in Streptococcus mutans.
Article in Molecular oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Perfectly Coupled Transcriptional Regulation of Fatty Acid Synthesis in Enterocci, Streptocci, and Lactococci.Molecular microbiology · 2026Article
- Bacterial acquisition of host fatty acids has far-reaching implications on virulence.Microbiology and molecular biology reviews : MMBR · 2024Review
- The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection.Nature communications · 2024Article
- Transcriptional control of carbohydrate catabolism by the CcpA protein in the ruminal bacteriumApplied and environmental microbiology · 2023Article
- FabT, a Bacterial Transcriptional Repressor That Limits Futile Fatty Acid Biosynthesis.Microbiology and molecular biology reviews : MMBR · 2022Review
- Article
- Repression of the TreR transcriptional regulator in Streptococcus mutans by the global regulator, CcpA.FEMS microbiology letters · 2021Article
- Transcriptome Analysis Reveals Catabolite Control Protein A Regulatory Mechanisms Underlying Glucose-Excess or -Limited Conditions in a Ruminal Bacterium,Frontiers in microbiology · 2021Article
- Article
- The local transcriptional regulators SacR1 and SacR2 act as repressors of fructooligosaccharides metabolism in Lactobacillus plantarum.Microbial cell factories · 2020Article
- Streptococcus mutans SpxA2 relays the signal of cell envelope stress from LiaR to effectors that maintain cell wall and membrane homeostasis.Molecular oral microbiology · 2020Article
- Synergism between Corynebacterium and Streptococcus sanguinis reveals new interactions between oral commensals.The ISME journal · 2020Article
- Disruption of l-Rhamnose Biosynthesis Results in Severe Growth Defects in Streptococcus mutans.Journal of bacteriology · 2020Article
- A fatty acid-binding protein ofThe Journal of biological chemistry · 2019Article
- Functional analysis of the role of CcpA in Lactobacillus plantarum grown on fructooligosaccharides or glucose: a transcriptomic perspective.Microbial cell factories · 2018Article
- Genomic assessment in Lactobacillus plantarum links the butyrogenic pathway with glutamine metabolism.Scientific reports · 2017Article
- Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis.Infection and immunity · 2016Article
- The essential genome of Streptococcus agalactiae.BMC genomics · 2016Article
- PlsX deletion impacts fatty acid synthesis and acid adaptation in Streptococcus mutans.Microbiology (Reading, England) · 2016Article
- Identification and functional analysis of the L-ascorbate-specific enzyme II complex of the phosphotransferase system in Streptococcus mutans.BMC microbiology · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
SMU.1745c, encoding a putative transcriptional regulator of the MarR family, maps to a location proximal to the fab gene cluster in Streptococcus mutans. Deletion of the SMU.1745c (fabTS m ) coding region resulted in a membrane fatty acid composition comprised of longer-chained, unsaturated fatty acids (UFA), compared with the parent strain. Previous reports have indicated a role for FabT in regulation of genes in the fab gene cluster in other organisms, through binding to a palindromic DNA sequence. Consensus FabT motif sequences were identified in S. mutans in the intergenic regions preceding fabM, fabTSm and fabK in the fab gene cluster. Chloramphenicol acetyltransferase (cat) reporter fusions, using the fabM promoter, revealed elevated transcription in a ∆fabTS m background. Transcription of fabTS m was dramatically elevated in cells grown at pH values of 5 and 7 in the ∆ fabTS m background. Transcription of fabTS m was also elevated in a strain carrying a deletion for the carbon catabolite repressor CcpA. Purified FabTS m and CcpA bound to the promoter regions of fabTS m and fabM. Hence, the data indicate that FabTS m acts as a repressor of fabM and fabTS m itself and the global regulator CcpA acts as a repressor for fabTS m .
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