ArticleThe European journal of neuroscience2014
Lesions to the CA2 region of the hippocampus impair social memory in mice.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed, 226 citations in OpenAlex.
- Hippocampal CA2 modulates trace fear conditioning through circuit-specific control of CA1.bioRxiv : the preprint server for biology · 2026Article
- Neuroligin1 in CCK-interneurons gates social memory formation via a disinhibitory microcircuit in the hippocampal CA2 in male mice.Nature communications · 2026Article
- Developmental CA2 perineuronal net reduction restores social memory in Shank3 mutant mice.Communications biology · 2026Article
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- D1/D5 receptor activation promotes long-term potentiation and synaptic tagging/capture in hippocampal area CA2.The FEBS journal · 2026Article
- Development of an automated approach for investigating social learning in mice.Frontiers in behavioral neuroscience · 2026Article
- Early life stress alters microglia in ventral hippocampus and dorsal CA2 associated with anxiety-like behavior in adolescent male rats.Experimental brain research · 2025Article
- Developmental CA2 perineuronal net reduction restores social memory inbioRxiv : the preprint server for biology · 2025Article
- Primary age-related tauopathy.Acta neuropathologica · 2025Review
- Hippocampal CA2 to CA1: A metaplastic switch for memory encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Enriched environment requires the remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer's mouse model.iScience · 2025Article
- CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndrome.bioRxiv : the preprint server for biology · 2025Article
- Modulation of aggression by social novelty recognition memory in the hippocampal CA2 region.Cell reports · 2025Article
- The ventral CA2 region of the hippocampus and its differential contributions to social memory and social aggression.Cell reports · 2025Article
- High-Throughput Proteoform Imaging for Revealing Spatial-Resolved Changes in Brain Tissues Associated with Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Intranasal Transplantation of Microbiota Derived from Parkinson's Disease Mice Induced Astrocyte Activation and Neurodegenerative Pathology from Nose to Brain.Brain sciences · 2025Article
- The effects of social loss and isolation on partner odor investigation and dopamine and oxytocin receptor expression in female prairie voles.Neuropharmacology · 2025Article
- Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats.Biological psychiatry · 2025Article
- MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity.Scientific reports · 2025Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The function of the CA2 region of the hippocampus is poorly understood. Although the CA1 and CA3 regions have been extensively studied, for years the CA2 region has primarily been viewed as a linking area between the two. However, the CA2 region is known to have distinct neurochemical and structural features that are different from the other parts of the hippocampus and in recent years it has been suggested that the CA2 region may play a role in the formation and/or recall of olfactory-based memories needed for normal social behavior. Although this hypothesis has been supported by hippocampal lesion studies that have included the CA2 region, no studies have attempted to specifically lesion the CA2 region of the hippocampus in mice to determine the effects on social recognition memory and olfaction. To fill this knowledge gap, we sought to perform excitotoxic N-methyl-D-aspartate lesions of the CA2 region and determine the effects on social recognition memory. We predicted that lesions of the CA2 region would impair social recognition memory. We then went on to test olfaction in CA2-lesioned mice, as social memory requires a functional olfactory system. Consistent with our prediction, we found that CA2-lesioned animals had impaired social recognition. These findings are significant because they confirmed that the CA2 region of the hippocampus is a part of the neural circuitry that regulates social recognition memory, which may have implications for our understanding of the neural regulation of social behavior across species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.