ArticleInternational journal of occupational and environmental health2014
Repeated formaldehyde inhalation impaired olfactory function and changed SNAP25 proteins in olfactory bulb.
Article in International journal of occupational and environmental health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Formaldehyde and Brain Disorders: A Meta-Analysis and Bioinformatics Approach.Neurotoxicity research · 2021Pooled it
- Predictors of Formaldehyde-related Adverse Symptoms Among Laboratory Users in a University in Malaysian Borneo.The Malaysian journal of medical sciences : MJMS · 2026Article
- Messenger RNA transcription levels of neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex components in the olfactory nerve system of the anadromous Pacific salmon, masu salmon Oncorhynchus masou.Fish physiology and biochemistry · 2024Article
- Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- Morphological evaluation using MRI of the olfactory filaments (fila) in a post-traumatic olfactory rat model.World journal of otorhinolaryngology - head and neck surgery · 2018Article
- Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals.Journal of occupational medicine and toxicology (London, England) · 2018Review
- The Effect of Environmental Enrichment on Glutathione-Mediated Xenobiotic Metabolism and Antioxidation in Normal Adult Mice.Frontiers in neurology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFormaldehyde inhalation exposure, which can occur through occupational exposure, can lead to sensory irritation, neurotoxicity, mood disorders, and learning and memory impairment. However, its influence on olfactory function is unclear.
objectivesTo investigate the mechanism and the effect of repeated formaldehyde inhalation exposure on olfactory function.
methodsRats were treated with formaldehyde inhalation (13·5±1·5 ppm, twice 30 minutes/day) for 14 days. Buried food pellet and locomotive activity tests were used to detect olfactory function and locomotion. Western blots were used to evaluate synaptosomal-associated protein 25 (SNAP25) protein levels in the olfactory bulb (OB) lysate and synaptosome, as well as mature and immature olfactory sensory neuron markers, olfactory marker protein (OMP), and Tuj-1. Real-time polymerase chain reaction (PCR) was used to detect SNAP25 mRNA amounts.
resultsRepeated formaldehyde inhalation exposure impaired olfactory function, whereas locomotive activities were unaffected. SNAP25 protein decreased significantly in the OB, but not in the occipital lobe. SNAP25 also decreased in the OB synaptosome when synaptophysin did not change after formaldehyde treatment. mRNA levels of SNAP25A and SNAP25B were unaffected. Mature and immature olfactory sensory neuron marker, OMP, and Tuj-1, did not change after formaldehyde treatment.
conclusionRepeated formaldehyde exposure impaired olfactory function by disturbing SNAP25 protein in the OB.
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