ArticleCell reports2014
Perturbation of NCOA6 leads to dilated cardiomyopathy.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
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- Multiomics analyses and machine learning of nuclear receptor coactivator 6 reveal its essential role in hepatocellular carcinoma.Cancer science · 2023Article
- Cadmium Toxicity Is Regulated by Peroxisome Proliferator-Activated Receptor δ in Human Proximal Tubular Cells.International journal of molecular sciences · 2022Article
- Effect of PIERCE1 on colorectal cancer.Experimental animals · 2020Article
- From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry.Antibodies (Basel, Switzerland) · 2020Article
- Article
- Human Induced Pluripotent Stem-Cell-Derived Cardiomyocytes as Models for Genetic Cardiomyopathies.International journal of molecular sciences · 2019Review
- Reconstruction and Analysis of the lncRNA-miRNA-mRNA Network Based on Competitive Endogenous RNA Reveal Functional lncRNAs in Dilated Cardiomyopathy.Frontiers in genetics · 2019Article
- Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing.Laboratory animal research · 2018Article
- CRISPR/Cas9-mediated generation of aLaboratory animal research · 2018Article
- Genotypic effect of a mutation of the MYBPC3 gene and two phenotypes with different patterns of inheritance.Journal of clinical laboratory analysis · 2018Article
- PIMT/NCOA6IP Deletion in the Mouse Heart Causes Delayed Cardiomyopathy Attributable to Perturbation in Energy Metabolism.International journal of molecular sciences · 2018Article
- CRISPR-Cas9-mediated generation of obese and diabetic mouse models.Experimental animals · 2018Article
- PPARNuclear receptor research · 2018Article
- Article
- Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice.PloS one · 2016Article
- Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy.International journal of molecular medicine · 2015Article
- Review
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Authors and funding
14 authors at 6 institutions in 3 countries.
Funding
Abstract
Dilated cardiomyopathy (DCM) is a progressive heart disease characterized by left ventricular dilation and contractile dysfunction. Although many candidate genes have been identified with mouse models, few of them have been shown to be associated with DCM in humans. Germline depletion of Ncoa6, a nuclear hormone receptor coactivator, leads to embryonic lethality and heart defects. However, it is unclear whether Ncoa6 mutations cause heart diseases in adults. Here, we report that two independent mouse models of NCOA6 dysfunction develop severe DCM with impaired mitochondrial function and reduced activity of peroxisome proliferator-activated receptor δ (PPARδ), an NCOA6 target critical for normal heart function. Sequencing of NCOA6-coding regions revealed three independent nonsynonymous mutations present in 5 of 50 (10%) patients with idiopathic DCM (iDCM). These data suggest that malfunction of NCOA6 can cause DCM in humans.
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