ReviewNeurobiology of learning and memory2014
Epigenetic mechanisms of memory formation and reconsolidation.
Review in Neurobiology of learning and memory, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 110 citations in OpenAlex.
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons.bioRxiv : the preprint server for biology · 2025Article
- Learning induces persistent chromatin loops underlying robust gene expression during memory recall.bioRxiv : the preprint server for biology · 2025Article
- Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence.Neuroscience and biobehavioral reviews · 2025Review
- Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy.Epilepsy & behavior reports · 2024Article
- Review
- Neuronal activation of GCell reports · 2023Article
- Epigenetic Processes of DNA Methylation Are Selectively Involved in the Mechanisms of Retrograde and Anteograde Amnesia.Bulletin of experimental biology and medicine · 2023Article
- Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome.Journal of neurotrauma · 2022Review
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory.International journal of molecular sciences · 2022Review
- Article
- Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Role of DNA Methylation and Activity of Neurotransmitter Receptors in the Mechanisms of Specific Anterograde Amnesia and Memory Recovery.Bulletin of experimental biology and medicine · 2022Article
- DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory.Frontiers in molecular neuroscience · 2022Article
- A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment.Frontiers in psychiatry · 2022Review
- Epigenetic Mechanisms in Memory and Cognitive Decline Associated with Aging and Alzheimer's Disease.International journal of molecular sciences · 2021Review
- A putative role for lncRNAs in epigenetic regulation of memory.Neurochemistry international · 2021Review
- Ubiquitination of Histone H2B by Proteasome Subunit RPT6 Controls Histone Methylation Chromatin Dynamics During Memory Formation.Biological psychiatry · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Memory consolidation involves transcriptional control of genes in neurons to stabilize a newly formed memory. Following retrieval, a once consolidated memory destabilizes and again requires gene transcription changes in order to restabilize, a process referred to as reconsolidation. Understanding the molecular mechanisms of gene transcription during the consolidation and reconsolidation processes could provide crucial insights into normal memory formation and memory dysfunction associated with psychiatric disorders. In the past decade, modifications of epigenetic markers such as DNA methylation and posttranslational modifications of histone proteins have emerged as critical transcriptional regulators of gene expression during initial memory formation and after retrieval. In light of the rapidly growing literature in this exciting area of research, we here examine the most recent and latest evidence demonstrating how memory acquisition and retrieval trigger epigenetic changes during the consolidation and reconsolidation phases to impact behavior. In particular we focus on the reconsolidation process, where we discuss the already identified epigenetic regulators of gene transcription during memory reconsolidation, while exploring other potential epigenetic modifications that may also be involved, and expand on how these epigenetic modifications may be precisely and temporally controlled by important signaling cascades critical to the reconsolidation process. Finally, we explore the possibility that epigenetic mechanisms may serve to regulate a system or circuit level reconsolidation process and may be involved in retrieval-dependent memory updating. Hence, we propose that epigenetic mechanisms coordinate changes in neuronal gene transcription, not only during the initial memory consolidation phase, but are triggered by retrieval to regulate molecular and cellular processes during memory reconsolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.