Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
The longitudinal effects of physical activity and dietary calcium on bone mass accrual across stages of pubertal development.
Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Change in physical activity from adolescence to early adulthood: a systematic review and meta-analysis of longitudinal cohort studies.British journal of sports medicine · 2019Pooled it
- The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Pooled it
- Beat osteoporosis - nourish and exercise skeletons (BONES): a group randomized controlled trial in children.BMC pediatrics · 2020Trial
- Soft tissues, areal bone mineral density and hip geometry estimates in active young boys: the PRO-BONE study.European journal of applied physiology · 2017Trial
- Enhancing Skeletal Health in Developmental Coordination Disorder: The Role of Calcium and Targeted Training in Children Bone Density Development.International journal of school health · 2026Article
- Review
- Race-neutral Pediatric Reference Ranges for Bone Mineral Density Predict Prospective Fractures in Childhood.The Journal of clinical endocrinology and metabolism · 2025Article
- Physiological and lifestyle determinants of bone mass in minority children/adolescents from the MetA-Bone Trial.Pediatric research · 2025Article
- Biological Benchmarks for Adult Bone Mass Proportions in Young Females: A Prospective Longitudinal Analysis.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Article
- Exposure to Residential Green Space and Bone Mineral Density in Young Children.JAMA network open · 2024Article
- Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Effect of emotion-based nutrition messages on consumption of calcium-rich foods among early adolescents in Ogbomoso, Nigeria.Dialogues in health · 2023Article
- Age-related trajectory of bone density in children with intestinal failure: A longitudinal retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Associations of urinary metabolite concentrations of phthalates and phthalate replacements with body composition from mid-childhood to early adolescence.Environmental research · 2023Article
- Histologic Severity of Nonalcoholic Fatty Liver Disease Associates with Reduced Bone Mineral Density in Children.Digestive diseases and sciences · 2023Article
- Adiposity, Insulin Resistance, Cardiorespiratory Fitness, and Bone Health in Hispanic Children.The Journal of clinical endocrinology and metabolism · 2022Article
- The Association between Lead Exposure and Bone Mineral Density in Childhood and Adolescence: Results from NHANES 1999-2006 and 2011-2018.Nutrients · 2022Article
- The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents.Frontiers in endocrinology · 2022Article
- Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.Genome biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Childhood and adolescence are critical periods of bone mineral content (BMC) accrual that may have long-term consequences for osteoporosis in adulthood. Adequate dietary calcium intake and weight-bearing physical activity are important for maximizing BMC accrual. However, the relative effects of physical activity and dietary calcium on BMC accrual throughout the continuum of pubertal development in childhood remains unclear. The purpose of this study was to determine the effects of self-reported dietary calcium intake and weight-bearing physical activity on bone mass accrual across the five stages of pubertal development in a large, diverse cohort of US children and adolescents. The Bone Mineral Density in Childhood study was a mixed longitudinal study with 7393 observations on 1743 subjects. Annually, we measured BMC by dual-energy X-ray absorptiometry (DXA), physical activity and calcium intake by questionnaire, and pubertal development (Tanner stage) by examination for up to 7 years. Mixed-effects regression models were used to assess physical activity and calcium intake effects on BMC accrual at each Tanner stage. We found that self-reported weight-bearing physical activity contributed to significantly greater BMC accrual in both sexes and racial subgroups (black and nonblack). In nonblack males, the magnitude of the activity effect on total body BMC accrual varied among Tanner stages after adjustment for calcium intake; the greatest difference between high- and low-activity boys was in Tanner stage 3. Calcium intake had a significant effect on bone accrual only in nonblack girls. This effect was not significantly different among Tanner stages. Our findings do not support differential effects of physical activity or calcium intake on bone mass accrual according to maturational stage. The study demonstrated significant longitudinal effects of weight-bearing physical activity on bone mass accrual through all stages of pubertal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.