ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2014
Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
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- Non-ToxigenicAntibiotics (Basel, Switzerland) · 2023Article
- Food for thought-The link between Clostridioides difficile metabolism and pathogenesis.PLoS pathogens · 2023Review
- Multi-omics investigation ofeLife · 2022Article
- Children gut microbiota exhibits a different composition and metabolic profile afterFrontiers in microbiology · 2022Article
- Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis.mSystems · 2021Article
- Mucin-Degrading Microbes Release Monosaccharides That ChemoattractACS infectious diseases · 2021Article
- Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence.NPJ systems biology and applications · 2020Article
- Diverse Energy-Conserving Pathways in Clostridium difficile: Growth in the Absence of Amino Acid Stickland Acceptors and the Role of the Wood-Ljungdahl Pathway.Journal of bacteriology · 2020Article
- The Impact of pH on Clostridioides difficile Sporulation and Physiology.Applied and environmental microbiology · 2020Article
- Ethanolamine is a valuable nutrient source that impacts Clostridium difficile pathogenesis.Environmental microbiology · 2018Article
- Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment ofFrontiers in microbiology · 2018Review
- Using phenotype microarrays in the assessment of the antibiotic susceptibility profile of bacteria isolated from wastewater in on-site treatment facilities.Folia microbiologica · 2017Article
- Control ofMicrobiology spectrum · 2017Review
- Comparative genomic and phenomic analysis of Clostridium difficile and Clostridium sordellii, two related pathogens with differing host tissue preference.BMC genomics · 2015Article
- Interactions Between the Gastrointestinal Microbiome and Clostridium difficile.Annual review of microbiology · 2015Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesClostridium difficile infection (CDI) is the leading cause of infectious diarrhea in North America and Europe. The risk of CDI increases significantly in the case where antimicrobial treatment reduces the number of competing bacteria in the gut, thus leading to the increased availability of nutrients and loss of colonization resistance. The objective of this study was to determine comprehensive nutritional utilization and the chemical sensitivity profile of historic and newer C. difficile isolates and to examine the possible role of the phenotype diversity in C. difficile virulence.
methodsPhenotype microarrays (PMs) were used to elucidate the complete nutritional and chemical sensitivity profile of six C. difficile isolates.
resultsOf the 760 nutrient sources tested, 285 compounds were utilized by at least one strain. Among the C. difficile isolates compared, R20291, a recent hypervirulent outbreak-associated strain, appears to have an expanded nutrient utilization profile when compared to all other strains.
conclusionsThe expanded nutritional utilization profile of some newer C. difficile strains could be one of the reasons for infections in patients who are not exposed to the hospital environment or not undergoing antibiotic treatment. This nutritional profile could be used to design tube feeding formulas that reduce the risk of CDI.
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