ArticleAmerican journal of human biology : the official journal of the Human Biology Council
The anthropometry of children and adolescents may be influenced by the prenatal smoking habits of their grandmothers: a longitudinal cohort study.
Article in American journal of human biology : the official journal of the Human Biology Council. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review.Journal of environmental and public health · 2018Pooled it
- Overweight/Obesity and Ancestral Environmental Smoking Exposures: A Summary of Results from the ALSPAC Cohort.The Yale journal of biology and medicine · 2025Article
- Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution.Epigenetics · 2024Review
- Grandmaternal smoking during pregnancy is associated with differential DNA methylation in peripheral blood of their grandchildren.European journal of human genetics : EJHG · 2022Article
- Paternal grandmother's smoking in pregnancy is associated with extreme aversion to bitter taste in their grandchildren.Environmental epigenetics · 2022Article
- Ancestral smoking and developmental outcomes: a review of publications from a population birth cohort†.Biology of reproduction · 2021Review
- Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren.JAMA network open · 2021Article
- Effect of Grandmaternal Smoking on Body Size and Proportions at Birth.International journal of environmental research and public health · 2021Article
- Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.International journal of epidemiology · 2020Article
- Establishing a three-generation prospective study: Bogalusa daughters.Journal of developmental origins of health and disease · 2020Article
- Prenatal anxiety, breastfeeding and child growth and puberty: linking evolutionary models with human cohort studies.Annals of human biology · 2020Article
- Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective.International journal of epidemiology · 2020Article
- Intolerance of loud sounds in childhood: Is there an intergenerational association with grandmaternal smoking in pregnancy?PloS one · 2020Article
- Grandchild's IQ is associated with grandparental environments prior to the birth of the parents.Wellcome open research · 2020Article
- Grandmothers' smoking in pregnancy is associated with a reduced prevalence of early-onset myopia.Scientific reports · 2019Article
- Investigating Possible Trans/Intergenerational Associations With Obesity in Young Adults Using an Exposome Approach.Frontiers in genetics · 2019Article
- Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.Scientific reports · 2018Article
- Does cross-generational epigenetic inheritance contribute to cultural continuity?Environmental epigenetics · 2018Article
- Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study.Journal of atherosclerosis and thrombosis · 2017Article
- Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism.Environmental epigenetics · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPreviously, in the Avon Longitudinal Study of Parents and Children (ALSPAC), we have shown different sex-specific birth anthropometric measurements contingent upon whether or not prenatal smoking was undertaken by paternal grandmother (PGM±), maternal grandmother (MGM±), and the study mother (M±). The findings raised the question as to whether there were long-term associations on the growth of the study children over time.
methodsMeasures of weight, height, body mass index, waist circumference, lean mass, and fat mass of children in the ALSPAC study from 7 to 17 years of age were used. We compared growth in four categories at each age: PGM+M- with PGM-M-; MGM+M- with MGM-M-; PGM+M+ with PGM-M+; MGM+M+ with MGM-M+; and adjusted for housing tenure, maternal education, parity, and paternal smoking at the start of the study pregnancy.
resultsWe found that if the PGM had, but the study mother had not, smoked in pregnancy, the girls were taller and both genders had greater bone and lean mass. However, if the MGM had smoked prenatally but the mother had not (MGM+M-), the boys became heavier than expected with increasing age-an association that was particularly due to lean rather than fat mass, reflected in increased strength and fitness. When both the maternal grandmother and the mother had smoked (MGM+M+) girls had reduced height, weight, and fat/lean/bone mass when compared with girls born to smoking mothers whose own mothers had not smoked (MGM-M+).
conclusionsThis study indicates that smoking in humans can have sex-specific transgenerational effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.