Trial reportThe Journal of allergy and clinical immunology2015
Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.
Trial report in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Respiratory virus type to guide predictive enrichment approaches in the management of the first episode of bronchiolitis: A systematic review.Frontiers in immunology · 2022Pooled it
- Safety of corticosteroids in young children with acute respiratory conditions: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Prednisolone for the first rhinovirus-induced wheezing and 4-year asthma risk: A randomized trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017Trial
- Vitamin D, virus etiology, and atopy in first-time wheezing children in Finland.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2014Trial
- Multiple Childhood Respiratory Viral Infections Are Associated with Allergy in Young Adults.International archives of allergy and immunology · 2026Article
- A single-centre randomised, feasibility study using point-of-care (POC) testing for respiratory viruses to direct oral corticosteroids use in preschool-aged children with acute wheeze: a protocol.Pilot and feasibility studies · 2026Article
- Article
- Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.American journal of respiratory and critical care medicine · 2024Review
- Disease Severity and Cytokine Expression in the Rhinovirus-Induced First Wheezing Episode.Viruses · 2024Article
- Human bocavirus 1 coinfection is associated with decreased cytokine expression in the rhinovirus-induced first wheezing episode in children.Clinical and translational allergy · 2023Article
- Clinical Outcomes of Acutely Ill Children According to Cycle Threshold Values of Respiratory Viruses Detected by Multiplex PCR Testing.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.The Journal of infectious diseases · 2023Article
- Proteomics endotyping of infants with severe bronchiolitis and risk of childhood asthma.Allergy · 2022Article
- Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations.Mucosal immunology · 2022Article
- Something Is Changing in Viral Infant Bronchiolitis Approach.Frontiers in pediatrics · 2022Review
- Cytokine expression in rhinovirus- vs. respiratory syncytial virus-induced first wheezing episode and its relation to clinical course.Frontiers in immunology · 2022Article
- Article
- Decoding Susceptibility to Respiratory Viral Infections and Asthma Inception in Children.International journal of molecular sciences · 2020Review
- Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children.The Pediatric infectious disease journal · 2020Observational
- Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.The journal of allergy and clinical immunology. In practice · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRhinovirus-induced wheezing is an important risk factor for recurrent wheezing. There are no randomized controlled trials on the effect of systemic corticosteroids in patients with this disease.
objectiveWe sought to study the short- and long-term effects of prednisolone treatment of the first acute, moderate-to-severe, rhinovirus-induced wheezing episode in young children.
methodsAfter confirming rhinovirus from nasopharyngeal aspirate by using PCR, 79 children with a first wheezing episode at age 3 to 23 months were randomized to receive oral prednisolone (first dose of 2 mg/kg, followed by 2 mg/kg/d in 2 divided doses for 3 days) or placebo. The trial was double blind throughout the 12-month follow-up. The primary outcomes were long term: new physician-confirmed wheezing episode within 2 months, number of physician-confirmed wheezing episodes within 12 months, and initiation of regular controller medication for asthma symptoms within 12 months. The primary interaction analysis examined rhinovirus load.
resultsSeventy-four patients completed the study (mean age, 13 months; 28% atopic). Long-term outcomes did not differ between groups (all P ≥ .30). For short-term outcomes, the prednisolone group had less cough, rhinitis, noisy breathing, severe breathing difficulties, and nocturnal respiratory symptoms at home within 2 weeks (all P < .05). The 25 children with greater than 7000 rhinovirus copies/mL (most sensitive cutoff) benefitted from prednisolone in terms of less risk of physician-confirmed recurrence within 2 and 12 months compared with placebo (both P < .05).
conclusionsPrednisolone cannot be routinely recommended for all young children experiencing their first acute, moderate-to-severe, rhinovirus-induced wheezing episode. Prednisolone might be beneficial in a subgroup of children with high viral loads.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.