Evidence map›Paper›PMID 25129405›Full record

Observational studyJournal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

A trimodality comparison of volumetric bone imaging technologies. Part I: Short-term precision and validity.

Andy K O Wong, Karen A Beattie, Kevin K H Min, Colin E Webber, Christopher L Gordon, Alexandra Papaioannou, Angela M W Cheung, Jonathan D Adachi

Open access · greenAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Andy K O WongDepartment of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: wongko@mcmaster.ca.
Karen A BeattieDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Kevin K H MinHealth Sciences, McMaster University, Hamilton, ON, Canada.
Colin E WebberDepartment of Nuclear Medicine, McMaster University, Hamilton, ON, Canada.
Christopher L GordonDepartment of Nuclear Medicine, McMaster University, Hamilton, ON, Canada.
Alexandra PapaioannouDivision of Geriatrics, Hamilton Health Sciences, Hamilton, ON, Canada.
Angela M W CheungOsteoporosis Program, University Health Network, Toronto, ON, Canada.
Jonathan D AdachiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
McMaster University · CAHamilton Health Sciences · CAUniversity Health Network · CA

Funding

CIHR 88225-1
6 · The paper itself

Abstract

In vivo peripheral quantitative computed tomography (pQCT) and peripheral magnetic resonance imaging (pMRI) modalities can measure apparent bone microstructure at resolutions 200 μm or higher. However, validity and in vivo test-retest reproducibility of apparent bone microstructure have yet to be determined on 1.0 T pMRI (196 μm) and pQCT (200 μm). This study examined 67 women with a mean age of 74±9 yr and body mass index of 27.65±5.74 kg/m2, demonstrating validity for trabecular separation from pMRI, cortical thickness, and bone volume fraction from pQCT images compared with high-resolution pQCT (hr-pQCT), with slopes close to unity. However, because of partial volume effects, cortical and trabecular thickness of bone derived from pMRI and pQCT images matched hr-pQCT more only when values were small. Short-term reproducibility of bone outcomes was highest for bone volume fraction (BV/TV) and densitometric variables and lowest for trabecular outcomes measuring microstructure. Measurements at the tibia for pQCT images were more precise than at the radius. In part I of this 3-part series focused on trimodality comparisons of precision and validity, it is shown that pQCT images can yield valid and reproducible apparent bone structural outcomes, but because of longer scan time and potential for more motion, the pMRI protocol examined here remains limited in achieving reliable values.

Indexed as

Bone and BonesBone DensityAgedBody Mass IndexCanadaComparative Effectiveness ResearchCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMultimodal ImagingReproducibility of ResultsTomography, X-Ray ComputedMRIpQCTsegmentationshort-term precisionvalidity

Identifiers

PMID25129405
PMCPMC5094893
OpenAlexW2094582231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.