Evidence map›Paper›PMID 25129146›Full record

ArticleNature genetics2014

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.

Chen Wu, Zhaoming Wang, Xin Song, Xiao-Shan Feng, Christian C Abnet, Jie He, Nan Hu, Xian-Bo Zuo, Wen Tan, Qimin Zhan and 138 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 6 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 6 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Molecular subtyping-guided precision therapy for ESCC: biomarker-driven strategies and clinical translation pathways.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  9. Review
  10. Article
  11. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Digestive cancers: mechanisms, therapeutics and management.Signal transduction and targeted therapy · 2025
    Review
  17. Assessment ofAnnals of medicine · 2024
    Article
  18. Article
  19. Article
  20. Review

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

148 authors at 20 institutions in 3 countries.

Chen Wu *State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhaoming Wang *Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Xin Song *Department of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Xiao-Shan Feng *Department of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
Christian C Abnet *Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Jie He *Department of Thoracic Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Nan Hu *Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Xian-Bo Zuo *Key Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
Wen Tan *State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qimin ZhanState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhibin HuDepartment of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Zhonghu HeKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
Weihua JiaState Key Laboratory of Oncology in Southern China.
Yifeng ZhouLaboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou, China.
Kai YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Xiao-Ou ShuDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Jian-Min YuanUniversity of Pittsburgh Cancer Institute, Pittsburg, PA, USA.
Wei ZhengDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Xue-Ke ZhaoHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
She-Gan GaoDepartment of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
Zhi-Qing YuanDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Fu-You ZhouAnyang Tumor Hospital, Anyang, Henan, China.
Zong-Min FanHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ji-Li CuiDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Hong-Li LinDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Xue-Na HanHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Bei LiHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xi ChenHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Sanford M DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Linda LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Maxwell P LeeCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ti DingShanxi Cancer Hospital, Taiyuan, Shanxi, China.
You-Lin QiaoDepartment of Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhihua LiuState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu LiuState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dianke YuState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jiang ChangState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lixuan WeiState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yu-Tang GaoShanghai Cancer Institute, Shanghai, People's Republic of China.
Woon-Puay KohDuke-National University of Singapore, Graduate Medical School, Singapore.
Yong-Bing XiangShanghai Cancer Institute, Shanghai, People's Republic of China.
Ze-Zhong TangShanxi Cancer Hospital, Taiyuan, Shanxi, China.
Jin-Hu FanDepartment of Epidemiology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jing-Jing HanHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Sheng-Li ZhouHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Peng ZhangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Dong-Yun ZhangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Yuan YuanHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ying HuangState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chunling LiuState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Kan ZhaiState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yan QiaoState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Guangfu JinDepartment of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Chuanhai GuoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
Jianhua FuState Key Laboratory of Oncology in Southern China.
Xiaoping MiaoKey Laboratory for Environment and Health (Ministry of Education), School of Public Health, Huazhong University of Sciences and Technology, Wuhan, China.
Changdong LuAnyang Tumor Hospital, Anyang, Henan, China.
Haijun YangAnyang Tumor Hospital, Anyang, Henan, China.
Chaoyu WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
William A WheelerInformation Management Services Inc., Silver Spring, Maryland, USA.
Mitchell GailDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Jeff YuengerDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Er-Tao GuoHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ai-Li LiHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Wei ZhangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xue-Min LiDepartment of Pathology and Thoracic Surgery, Centre for Health Screening and Endoscopy, Cixian Hospital, Cixian, Hebei, China.
Liang-Dan SunKey Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
Bao-Gen MaDepartment of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Yan LiHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Sa TangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xiu-Qing PengHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Jing LiuHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Kevin JacobsDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Carol GiffenInformation Management Services Inc., Silver Spring, Maryland, USA.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Yang KeKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
Yixin ZengState Key Laboratory of Oncology in Southern China.
Tangchun WuKey Laboratory for Environment and Health (Ministry of Education), School of Public Health, Huazhong University of Sciences and Technology, Wuhan, China.
Peter KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Charles C ChungDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Margaret A TuckerDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Zhi-Chao HouHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ya-Li LiuDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Yan-Long HuDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Yu LiuHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Li WangDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Guo YuanDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Li-Sha ChenDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Xiao LiuHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Teng MaHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Hui MengHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Li SunHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xin-Min LiHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xiu-Min LiDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Jian-Wei KuHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ying-Fa ZhouHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Liu-Qin YangDepartment of Radiotherapy, Pathology and Pediatrics, Central Hospital of Xinxiang, Xinxiang, Henan, China.
Zhou WangDepartment of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Yin LiDepartment of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province, Zhengzhou, Henan, China.
Qirenwang QigeDepartment of Internal Mongolia Medicine, The Affiliated Hospital, Inner Mongolia Medical College, Huhhot, Inner Mongolia, China.
Wen-Jun YangDepartment of Biotechnology, Ningxia Medical University, Yinchuan, Ningxia, China.
Guang-Yan LeiDepartment of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Xi'an, Shaanxi, China.
Long-Qi ChenDepartment of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
En-Min LiDepartment of Oncologic Pathology, Medical College of Shantou University, Shantou, Guangdong, China.
Ling YuanDepartment of Thoracic Surgery and Radiotherapy, Cancer Hospital of Henan Province, Zhengzhou, Henan, China.
Wen-Bin YueHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ran WangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Lu-Wen WangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Xue-Ping FanHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Fang-Heng ZhuDepartment of Radiotherapy, Pathology and Pediatrics, Central Hospital of Xinxiang, Xinxiang, Henan, China.
Wei-Xing ZhaoDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Yi-Min MaoDepartment of Oncology, Pathology, Clinical Laboratory and Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, Henan, China.
Mei ZhangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Guo-Lan XingHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Ji-Lin LiDepartment of Pathology and Thoracic Surgery, Linzhou Esophageal Cancer Hospital, Linzhou, Henan, China.
Min HanDepartment of Gastroenterology and Thoracic Surgery, The First People's Hospital of Shangqiu, Shangqiu, Henan, China.
Jing-Li RenDepartment of Basic Oncology, Pathology and Gastroenterology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Bin LiuDepartment of Gastroenterology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China.
Shu-Wei RenDepartment of Oncology, Xinyang Central Hospital, Xinyang, Henan, China.
Qing-Peng KongState Key Laboratory of Genetic Resource and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Feng LiDepartment of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Ilyar SheyhidinDepartment of Thoracic Surgery, Xinjiang Medical University, Urumqi, Xinjiang, China.
Wu WeiInstitute of Hematologic Disease, Changzhi Medical University, Changzhi, Shanxi, China.
Yan-Rui ZhangDepartment of Gastroenterology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Chang-Wei FengDepartment of Basic Oncology, Pathology and Gastroenterology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Jin WangHenan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China.
Yu-Hua YangDepartment of Surgery, Hebi Dahejian Hospital, Hebi, Henan, China.
Hong-Zhang HaoAnyang District Hospital, Anyang, Henan, China.
Qi-De BaoAnyang District Hospital, Anyang, Henan, China.
Bao-Chi LiuSurgical Department of Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Ai-Qun WuDepartment of Anatomy, the Second Military Medical University of Chinese PLA, Shanghai, China.
Dong XieInstitute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Wan-Cai YangDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Liang WangDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Xiao-Hang ZhaoNational Laboratory of Molecular Oncology, Cancer Institute & Hospital, CAMS, Beijing, China.
Shu-Qing ChenCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Jun-Yan HongCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.
Xue-Jun ZhangKey Laboratory of Dermatology, Anhui Medical University, Anhui, Hefei, China.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Dongxin LinState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Li-Dong WangDepartment of Pathology, Cancer Research Center, Basic Medical College, Xinxiang Medical University, Xinxiang, Henan, China.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA.
Zhengzhou University · CNNational Institutes of Health · USChinese Academy of Medical Sciences & Peking Union Medical College · CNAnyang Tumor Hospital · CNAnhui Medical University · CNMedical College of Wisconsin · USFirst Affiliated Hospital of Henan University of Science and Technology · CNHarvard University · USNanjing Medical University · CNPeking University · CNSun Yat-sen University · CNBeijing Tongren Hospital · CNHenan Provincial People's Hospital · CNHuazhong University of Science and Technology · CNInformation Management Services · USNingxia Medical University · CNSecond Affiliated Hospital of Zhengzhou University · CNShanghai Cancer Institute · CNShanxi Provincial Cancer Hospital · CNSichuan University · CN

Funding

Nutrition Intervention Trials in Linxian ChinaZIACP000112 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$8.2M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
Cohort Study of Cancer inhibitory Factors in MenR01CA082729 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 2001 to 2011
$6.3M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
UGI Cancer Genetic StudiesZIACP000150 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI TAYLOR, PHILIP · 2009 to 2011
$4.1M
CLINICAL/IMMUNOLOGIC/GENETIC ANALYSES OF AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROMEZ01AI000732 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI RAO, VEMULKONDA · 1995 to 2008
$1.1M
ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGYR35CA053890 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1998
–
EARLY DETECTION OF PANCREATIC ADENOCARCINOMASR03CA070837 · NCI · WASHINGTON UNIVERSITY · PI GOODFELLOW, PAUL JOSEPH · 1996 to 1997
–
COHORT STUDY OF DIET AND NASOPHYARYNGEAL CANCERR01CA055069 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIMI C. · 1992 to 1992
–
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA CP000112Intramural NIH HHS ZIA CP000150NCI NIH HHS HHSN261200477001CNCI NIH HHS HHSN261200800001ENCI NIH HHS N02 CP011010NCI NIH HHS R01 CA055069NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA082729NCI NIH HHS R01 CA144034NCI NIH HHS R01 CA80205NCI NIH HHS R01 CA82729NCI NIH HHS R35 CA053890NCI NIH HHS R37 CA70837NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182910
6 · The paper itself

Abstract

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) in individuals of Chinese ancestry (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.82-0.88; P = 7.72 × 10(-20)) and rs1642764 at 17p13.1 (per-allele OR = 0.88, 95% CI = 0.85-0.91; P = 3.10 × 10(-13)). rs7447927 is a synonymous SNP in TMEM173, and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR = 1.33, 95% CI = 1.22-1.46; P = 1.99 × 10(-10)). Our joint analysis identifies new ESCC susceptibility loci overall as well as a new locus unique to the population in the Taihang Mountain region at high risk of ESCC.

Indexed as

AllelesAsian PeopleCarcinoma, Squamous CellCase-Control StudiesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk

Identifiers

PMID25129146
PMCPMC4212832
OpenAlexW2003751484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.