ArticleNature genetics2014
Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 64 citations in OpenAlex.
- A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation.Blood advances · 2024Article
- Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans.BMC genomics · 2024Article
- Case report: Granulocyte-macrophage colony-stimulating factor sargramostim did not rescue the neutrophil phenotype in two patients with JAGN1-mutant severe congenital neutropenia.Frontiers in immunology · 2024Article
- Revisiting the immunopathology of congenital disorders of glycosylation: an updated review.Frontiers in immunology · 2024Review
- JAGN1 mutation with distinct clinical features; two case reports and literature review.BMC pediatrics · 2023Review
- Severe congenital neutropenia due to jagunal homolog 1 (Frontiers in pediatrics · 2023Article
- Pathogenesis and virulence ofVirulence · 2022Review
- Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.Frontiers in immunology · 2022Article
- Developmental defects and behavioral changes in a diet-induced inflammation model of zebrafish.Frontiers in immunology · 2022Article
- The δ subunit of FNature communications · 2021Article
- HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Identification ofPathogens (Basel, Switzerland) · 2021Article
- The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.Cell reports · 2021Article
- Immune Sensing ofJournal of fungi (Basel, Switzerland) · 2021Review
- A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.The Journal of experimental medicine · 2021Article
- Severe congenital neutropenia-associated JAGN1 mutations unleash a calpain-dependent cell death programme in myeloid cells.British journal of haematology · 2021Article
- JAGN1, tetraspanins, and Erv proteins: is common topology indicative of common function in cargo sorting?American journal of physiology. Cell physiology · 2020Article
- The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways.Scientific reports · 2019Article
- Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity.The Journal of clinical investigation · 2019Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Funding
Abstract
Neutrophils are key innate immune effector cells that are essential to fighting bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagn1 (encoding Jagunal homolog 1) cannot mount an efficient neutrophil-dependent immune response to the human fungal pathogen Candida albicans. Global glycobiome analysis identified marked alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity in Jagn1-deficient neutrophils. Functional analysis confirmed marked defects in neutrophil migration in response to Candida albicans infection and impaired formation of cytotoxic granules, as well as defective myeloperoxidase release and killing of Candida albicans. Treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF) protected mutant mice from increased weight loss and accelerated mortality after Candida albicans challenge. Notably, GM-CSF also restored the defective fungicidal activity of bone marrow cells from humans with JAGN1 mutations. These data directly identify Jagn1 (JAGN1 in humans) as a new regulator of neutrophil function in microbial pathogenesis and uncover a potential treatment option for humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.