ArticleNature chemical biology2014
A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana.
Article in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 89 citations in OpenAlex.
- Transcending the jasmonate-mediated growth-defense trade-off: Pathways to unlocking plant potential.Plant communications · 2026Review
- Integrative Analysis of Metabolic Signature and Phytohormone Response in Potato Under Heat, Drought and Salt Stresses.Plants (Basel, Switzerland) · 2026Article
- Rhizosphere microbial shifts drive amygdalin detoxification and jasmonate-mediated alleviation of peach autotoxicity.The ISME journal · 2026Article
- High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency.Frontiers in plant science · 2026Review
- Rapid local and systemic jasmonate signalling drives the initiation and establishment of plant systemic immunity.Nature plants · 2026Article
- Overexpression MsJAR1 gene increased lateral branches and plant height in alfalfa (Medicago sativa L.).Scientific reports · 2025Article
- Harnessing Jasmonate Pathways: PgJAR1's Impact on Ginsenoside Accumulation in Ginseng.Plants (Basel, Switzerland) · 2025Article
- Genome-wide identification and expression characterization of the GH3 gene family of tea plant (Camellia sinensis).BMC genomics · 2024Article
- Jarin-1, an inhibitor of JA-Ile biosynthesis inPlant signaling & behavior · 2023Article
- Metabolomic analysis of methyl jasmonate treatment on phytocannabinoid production inFrontiers in plant science · 2023Article
- An open source plant kinase chemogenomics set.Plant direct · 2022Article
- Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Comparative Transcriptome Analysis of Deep-Rooting and Shallow-Rooting Potato (Plants (Basel, Switzerland) · 2022Article
- Mechanisms of far-red light-mediated dampening of defense against Botrytis cinerea in tomato leaves.Plant physiology · 2021Article
- A small molecule antagonizes jasmonic acid perception and auxin responses in vascular and nonvascular plants.Plant physiology · 2021Article
- Discovery and characterization of small molecule inhibitors of cystathionine gamma-synthase with in planta activity.Plant biotechnology journal · 2021Article
- Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor.RSC chemical biology · 2021Article
- Interrogating Plant-Microbe Interactions with Chemical Tools: Click Chemistry Reagents for Metabolic Labeling and Activity-Based Probes.Molecules (Basel, Switzerland) · 2021Review
- Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1Chemistry of heterocyclic compounds · 2021Article
- Quantitative Trait Loci and Transcriptome Analysis Reveal Genetic Basis of Fiber Quality Traits in CCRI70 RIL Population ofFrontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Jasmonates are lipid-derived plant hormones that regulate plant defenses and numerous developmental processes. Although the biosynthesis and molecular function of the most active form of the hormone, (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile), have been unraveled, it remains poorly understood how the diversity of bioactive jasmonates regulates such a multitude of plant responses. Bioactive analogs have been used as chemical tools to interrogate the diverse and dynamic processes of jasmonate action. By contrast, small molecules impairing jasmonate functions are currently unknown. Here, we report on jarin-1 as what is to our knowledge the first small-molecule inhibitor of jasmonate responses that was identified in a chemical screen using Arabidopsis thaliana. Jarin-1 impairs the activity of JA-Ile synthetase, thereby preventing the synthesis of the active hormone, JA-Ile, whereas closely related enzymes are not affected. Thus, jarin-1 may serve as a useful chemical tool in search for missing regulatory components and further dissection of the complex jasmonate signaling networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.