Evidence map›Paper›PMID 25128762›Full record

ArticleVirology2014

Virus-host mucosal interactions during early SIV rectal transmission.

Wuxun Lu, Fangrui Ma, Alexander Churbanov, Yanmin Wan, Yue Li, Guobin Kang, Zhe Yuan, Dong Wang, Chi Zhang, Jianqing Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wuxun LuNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Fangrui MaNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Alexander ChurbanovNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Yanmin WanShanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.
Yue LiCollege of Life Sciences, Nankai University, Tianjin, China; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Guobin KangNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Zhe YuanNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Dong WangDepartment of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Chi ZhangSchool of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Jianqing XuShanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China; State Key Laboratory for Infectious Disease Prevention and Control, China CDC, Beijing, China.
Mark LewisBIOQUAL, Inc., Rockville, MD 20850, USA.
Qingsheng LiNebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA. Electronic address: qli@unl.edu.
University of Nebraska–Lincoln · USShanghai Public Health Clinical Center · CNBioqual · US

Funding

Supplement: Fogarty Training in HIV- and AIDS Associated Diseases/MalignanciesD43TW001429 · FIC · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2000 to 2015
$7.2M
Improve the safety of an efficacious live-attenuated HIV-1 vaccine through unnatuR01AI111862 · NIAID · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO, LI, QINGSHENG · 2014 to 2017
$1.9M
The Early Events Determining SIV Rectal TransmissionR01DK087625 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI LI, QINGSHENG · 2010 to 2013
$1.4M
FIC NIH HHS D43 TW001429FIC NIH HHS D43TW001429NIAID NIH HHS N01 AI030018NIAID NIH HHS N01-AI-30018NIAID NIH HHS R01 AI111862NIDDK NIH HHS R01 DK087625NIDDK NIH HHS R01DK087625
6 · The paper itself

Abstract

To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10 dpi. Our results suggest that the failure of the host to contain virus replication at the portal of entry is attributable to both a high-level expression of lymphocyte chemoattractant, proinflammatory and immune activation genes, which can recruit and activate viral susceptible target cells into mucosa; and a high-level expression of SIV accessory genes, which are known to be able to counter and evade host restriction factors and innate immune responses. This study provides new insights into the mechanism of rectal transmission.

Indexed as

AnimalsCytokinesDisease Models, AnimalHIV-1HIV InfectionsHost-Pathogen InteractionsHumansIntestinal MucosaMacaca mulattaMaleRectumSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusCytokinesmRNA-seqMucosal responseRectal transmissionSimian immunodeficiency virus (SIV)

Identifiers

PMID25128762
PMCPMC4808581
OpenAlexW2009709037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.