Evidence map›Paper›PMID 25128732›Full record

ReviewSeminars in cell & developmental biology2014

Patterning the renal vascular bed.

Doris Herzlinger, Romulo Hurtado

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Platelets in Renal Disease.International journal of molecular sciences · 2023
    Review
  6. The Beauty and Complexity of Blood Vessel Patterning.Cold Spring Harbor perspectives in medicine · 2022
    Review
  7. Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.Journal of the American Society of Nephrology : JASN · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Development of the Mammalian Kidney.Current topics in developmental biology · 2016
    Review
  19. Article
  20. Kidney Regeneration: Lessons from Development.Current pathobiology reports · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Doris HerzlingerDepartment of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Ave, New York, NY, United States. Electronic address: daherzli@med.cornell.edu.
Romulo HurtadoDepartment of Physiology and Biophysics, Weill Cornell Medical College, 1300 York Ave, New York, NY, United States.

Funding

Urogenital System Development: The Acquisition of Coordinated Ureter PeristalsisR01DK045218 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERZLINGER, DORIS A · 1991 to 2015
$5.7M
Resource Development Center: Real Time Imaging of Urinary Tract Smooth Muscle FunP20DK103072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERZLINGER, DORIS A · 2014 to 2015
$678k
Pbx1 transcriptional regulation in renal vascular mural cellsR56DK110468 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HERZLINGER, DORIS A · 2016 to 2016
$170k
GENERATION OF RENAL EPITHELIAL CELL DIVERSITYR55DK045218 · NIDDK · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI HERZLINGER, DORIS A · 1994 to 1994
–
NIDDK NIH HHS DK45218NIDDK NIH HHS P20 DK103072NIDDK NIH HHS R01 DK045218NIDDK NIH HHS R56 DK110468
6 · The paper itself

Abstract

The renal vascular bed has a stereotypic architecture that is essential for the kidney's role in excreting metabolic waste and regulating the volume and composition of body fluids. The kidney's excretory functions are dependent on the delivery of the majority of renal blood flow to the glomerular capillaries, which filter plasma removing from it metabolic waste, as well as vast quantities of solutes and fluids. The renal tubules reabsorb from the glomerular filtrate solutes and fluids required for homeostasis, while the post-glomerular capillary beds return these essential substances back into the systemic circulation. Thus, the kidney's regulatory functions are dependent on the close proximity or alignment of the post-glomerular capillary beds with the renal tubules. This review will focus on our current knowledge of the mechanisms controlling the embryonic development of the renal vasculature. An understanding of this process is critical for developing novel therapies to prevent vessel rarefaction and will be essential for engineering renal tissues suitable for restoring kidney function to the ever-increasing population of patients with end stage renal disease.

Indexed as

HumansKidneyKidney DiseasesKidney GlomerulusKidney TubulesNeovascularization, PhysiologicAngiogeneisKidney developmentVascular patterningVasculogenesis

Identifiers

PMID25128732
PMCPMC4447129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.