ArticleNeuroImage2014
Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7 T.
Article in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.Magnetic resonance in medicine · 2025Guideline
- An open-source stereotaxic container with an integrated cutting guide for human brain fixation during magnetic resonance imaging and sectioning for histology.bioRxiv : the preprint server for biology · 2026Article
- Diffusion-weighted steady-state free precession imaging in the ex vivo macaque brain on a 10.5T human MRI scanner.bioRxiv : the preprint server for biology · 2025Article
- Correlating hippocampal and amygdala volumes with neuropathological burden in Down syndrome and Alzheimer's disease and related neurodegenerative pathologies using 7T postmortem MRI.Journal of neuropathology and experimental neurology · 2025Article
- Investigating time-independent and time-dependent diffusion phenomena using steady-state diffusion MRI.Scientific reports · 2025Article
- Magnetic resonance imaging of postmortem human brain specimens: methodological considerations and prospects in psychoradiology.Psychoradiology · 2025Article
- Beyond the surface: howFrontiers in neuroscience · 2024Review
- A temperature-controlled cooling system for accurate quantitative post-mortem MRI.Magnetic resonance in medicine · 2023Article
- Magnetic resonance imaging at 9.4 T: the Maastricht journey.Magma (New York, N.Y.) · 2023Review
- High-fidelity, high-spatial-resolution diffusion magnetic resonance imaging of ex vivo whole human brain at ultra-high gradient strength with structured low-rank echo-planar imaging ghost correction.NMR in biomedicine · 2023Article
- Tensor image registration library: Deformable registration of stand-alone histology images to whole-brain post-mortem MRI data.NeuroImage · 2023Article
- An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons.NeuroImage · 2022Article
- Review
- Social connections predict brain structure in a multidimensional free-ranging primate society.Science advances · 2022Article
- Article
- A method to remove the influence of fixative concentration on postmortem THuman brain mapping · 2021Article
- Use of multi-flip angle measurements to account for transmit inhomogeneity and non-Gaussian diffusion in DW-SSFP.NeuroImage · 2020Article
- Modeling an equivalent b-value in diffusion-weighted steady-state free precession.Magnetic resonance in medicine · 2020Article
- Ex vivo diffusion MRI of the human brain: Technical challenges and recent advances.NMR in biomedicine · 2019Article
- Identification of the pedunculopontine nucleus and surrounding white matter tracts on 7T diffusion tensor imaging, combined with histological validation.Surgical and radiologic anatomy : SRA · 2019Article
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7 authors.
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Abstract
Post-mortem diffusion imaging of whole, human brains has potential to provide data for validation or high-resolution anatomical investigations. Previous work has demonstrated improvements in data acquired with diffusion-weighted steady-state free precession (DW-SSFP) compared with conventional diffusion-weighted spin echo at 3T. This is due to the ability of DW-SSFP to overcome signal-to-noise and diffusion contrast losses brought about by tissue fixation related decreases in T2 and ADC. In this work, data of four post-mortem human brains were acquired at 3T and 7 T, using DW-SSFP with similar effective b-values (b(eff)~5150 s/mm(2)) for inter-field strength comparisons; in addition, DW-SSFP data were acquired at 7 T with higher b(eff) (~8550 s/mm(2)) for intra-field strength comparisons. Results demonstrate that both datasets acquired at 7 T had higher SNR and diffusion contrast than data acquired at 3T, and data acquired at higher b(eff) had improved diffusion contrast than at lower b(eff) at 7 T. These results translate to improved estimates of secondary fiber orientations leading to higher fidelity tractography results compared with data acquired at 3T. Specifically, tractography streamlines of cortical projections originating from the corpus callosum, corticospinal tract, and superior longitudinal fasciculus were more successful at crossing the centrum semiovale and projected closer to the cortex. Results suggest that DW-SSFP at 7 T is a preferential method for acquiring diffusion-weighted data of post-mortem human brain, specifically where the primary region of interest involves crossing white matter tracts.
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