ArticleAmerican journal of ophthalmology2014
The role of magnetic resonance imaging in diagnosing optic nerve hypoplasia.
Article in American journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Pituitary deficiencies related to optic nerve hypoplasia and visual acuity.Clinical endocrinology · 2024Article
- Automatic segmentation and quantification of the optic nerve on MRI using a 3D U-Net.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Normative magnetic resonance imaging measurements of orbital structures in pediatric population of North-Eastern India: A retrospective cross-sectional study.Indian journal of ophthalmology · 2021Article
- Spotlight on the pediatric eye: a pictorial review of orbital anatomy and congenital orbital pathologies.The neuroradiology journal · 2021Review
- Pediatric optic nerve and optic nerve sheath diameter on magnetic resonance imaging.Pediatric radiology · 2019Article
- Neuro-Ophthalmological Manifestations Of Septo-Optic Dysplasia: Current Perspectives.Eye and brain · 2019Review
- Normal measurements of the optic nerve, optic nerve sheath and optic chiasm in the adult population.SA journal of radiology · 2019Article
- Optic Nerve Measurement on MRI in the Pediatric Population: Normative Values and Correlations.AJNR. American journal of neuroradiology · 2018Article
- Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1.Neurology · 2016Article
- Size of the intracranial optic nerve and optic tract in neonates at term-equivalent age at magnetic resonance imaging.Pediatric radiology · 2016Article
- Disruptive SCYL1 Mutations Underlie a Syndrome Characterized by Recurrent Episodes of Liver Failure, Peripheral Neuropathy, Cerebellar Atrophy, and Ataxia.American journal of human genetics · 2015Article
- Quantitative characterization of optic nerve atrophy in patients with multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Correlation of optic nerve on magnetic resonance imaging with visual acuity in children with cerebral visual impairment.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo establish objective lower limits of normal optic nerve (ON) size in children based on high-resolution orbital magnetic resonance imaging (MRI).
designCase-control study of patients with ON hypoplasia vs normal controls.
methodsA neuroradiologist made 4 measurements of each ON at 2 locations (5 mm posterior to the optic disc and just posterior to the optic canal) in patients with ON hypoplasia and controls aged 0-17 years from an academic eye center and children's hospital. Primary analyses were performed using mixed linear models.
resultsMeasurements were made in 26 cases of clinically confirmed ON hypoplasia and 31 controls (median age: ON hypoplasia, 1 year; controls, 5.5 years). Nine of 26 cases (35%) and 19 of 31 controls (61%) underwent high-resolution T2-weighted imaging of the orbits. Mean ON diameter was 1.36 mm (95% CI: 1.19-1.54; P < .001) smaller for clinically hypoplastic ONs than for controls. Optic nerve diameter increased by 0.05 mm per year of age (95% CI: 0.03-0.07; P < .001). A lower bound to the 95% prediction interval for normal optic nerves was (2.24 mm + 0.052 × [age in years]) mm and excluded all but 1 case.
conclusionsAge was independently associated with normal ON size by MRI and should be taken into consideration when evaluating ON hypoplasia, based on MRI criteria. We have provided a formula to assist clinicians in objectively determining if ON hypoplasia is present.
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