ArticleAmerican journal of obstetrics and gynecology2015
Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque.
Article in American journal of obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Animal experimental research assessing urogynecologic surgical mesh implants: Outcome measures describing the host response, a systematic review and meta-analysis.Neurourology and urodynamics · 2021Pooled it
- The Design of a Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse: Vaginal Hysterectomy With Native Tissue Vault Suspension Versus Mesh Hysteropexy Suspension (The Study of Uterine Prolapse Procedures Randomized Trial).Female pelvic medicine & reconstructive surgeryTrial
- Macrophage-to-myofibroblast transition (MMT) - An adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model.Biomaterials · 2026Article
- Macrophage-to-Myofibroblast Transition (MMT) - an adverse response to polypropylene mesh implanted for pelvic organ prolapse repair surgery in a non-human primate model.bioRxiv : the preprint server for biology · 2025Article
- Profiling of the macrophage response to polypropylene mesh burden in vivo.Biomaterials · 2025Article
- Polypropylene surgical mesh induces lipid oxidation in a nonhuman primate model.Acta biomaterialia · 2025Article
- Vaginal host response to polycarbonate urethane, an alternative material for the repair of pelvic organ prolapse.Acta biomaterialia · 2024Article
- Supramolecular Fibrous Hydrogel Augmentation of Uterosacral Ligament Suspension for Treatment of Pelvic Organ Prolapse.Advanced healthcare materials · 2023Article
- Laparoscopic sacrocolpopexy mesh excision step-by-step.International urogynecology journal · 2023Article
- Absorbable Electrospun Poly-4-hydroxybutyrate Scaffolds as a Potential Solution for Pelvic Organ Prolapse Surgery.ACS applied bio materials · 2022Article
- Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo.Acta biomaterialia · 2022Article
- Complications Reported to the Food and Drug Administration: A Cross-sectional Comparison of Urogynecologic Meshes.Female pelvic medicine & reconstructive surgery · 2022Article
- Characterization of vaginal immune response to a polypropylene mesh: Diabetic vs. normoglycemic conditions.Acta biomaterialia · 2022Article
- Comparison of treatment outcomes for native tissue repair and sacrocolpopexy as apical suspension procedures at the time of hysterectomy for uterine prolapse.Scientific reports · 2021Article
- Immunochemical analysis on polypropylene mesh: does mesh size make a difference?International urogynecology journal · 2021Article
- In Vitro Bacterial Adhesion and Biofilm Formation on Fully Absorbable Poly-4-hydroxybutyrate and Nonabsorbable Polypropylene Pelvic Floor Implants.ACS applied materials & interfaces · 2020Article
- Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction.Nanomaterials (Basel, Switzerland) · 2020Review
- Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders.World journal of clinical cases · 2020Review
- Electrospun Nanofiber Meshes With Endometrial MSCs Modulate Foreign Body Response by Increased Angiogenesis, Matrix Synthesis, and Anti-Inflammatory Gene Expression in Mice: Implication in Pelvic Floor.Frontiers in pharmacology · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveThe impact of polypropylene mesh implantation on vaginal collagen and elastin metabolism was analyzed using a nonhuman primate model to further delineate the mechanism of mesh induced complications. STUDY
designForty-nine middle-aged parous rhesus macaques underwent surgical implantation of 3 synthetic meshes via sacrocolpopexy. Gynemesh PS (n = 12) (Ethicon, Somerville, NJ) and 2 lower-weight, higher-porosity, lower-stiffness meshes (UltraPro [n = 19] [Ethicon] and Restorelle [n = 8] [Coloplast, Minneapolis, MN]) were implanted, in which UltraPro was implanted with its blue orientation lines perpendicular (low stiffness direction, n = 11) and parallel (high stiffness direction, n = 8) to the longitudinal axis of the vagina. Sham-operated animals were used as controls (n = 10). Twelve weeks after surgery, the mesh-tissue complex was excised and analyzed.
resultsRelative to sham, Gynemesh PS had a negative impact on the metabolism of both collagen and elastin-favoring catabolic reactions, whereas UltraPro induced an increase only in elastin degradation. Restorelle had the least impact. As compared with sham, the degradation of collagen and elastin in the vagina implanted with Gynemesh PS was increased with a simultaneous increase in active matrix metalloproteinase (MMP)-1, -8, -13, and total MMP-2 and -9 (all P < .05). The degradation of elastin (tropoelastin and mature elastin) was increased in the UltraPro-implanted vagina with a concomitant increase of MMP-2, and -9 (all P < .05). Collagen subtype ratio III/I was increased in Gynemesh PS and UltraPro perpendicular groups (P < .05).
conclusionFollowing implantation with the heavier, less porous, and stiffer mesh, Gynemesh PS, the degradation of vaginal collagen and elastin exceeded synthesis, most likely as a result of increased activity of MMPs, resulting in a structurally compromised tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.