ArticleG3 (Bethesda, Md.)2014
Widespread genomic incompatibilities in Caenorhabditis elegans.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- A role for worm cutl-24 in background- and parent-of-origin-dependent ER stress resistance.BMC genomics · 2022Article
- Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry.PLoS genetics · 2022Article
- Linkage mapping reveals loci that underlie differences in Caenorhabditis elegans growth.G3 (Bethesda, Md.) · 2022Article
- Hybrid fitness effects modify fixation probabilities of introgressed alleles.G3 (Bethesda, Md.) · 2022Article
- Article
- Review
- From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Trends in genetics : TIG · 2021Review
- The genetics of gene expression in a Caenorhabditis elegans multiparental recombinant inbred line population.G3 (Bethesda, Md.) · 2021Article
- Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.PLoS genetics · 2020Article
- The GeneG3 (Bethesda, Md.) · 2020Article
- Dissecting the eQTL Micro-Architecture inFrontiers in genetics · 2020Article
- WormQTL2: an interactive platform for systems genetics in Caenorhabditis elegans.Database : the journal of biological databases and curation · 2020Article
- Tightly linked antagonistic-effect loci underlie polygenic phenotypic variation inEvolution letters · 2019Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- A Novel Gene Underlies Bleomycin-Response Variation inGenetics · 2019Article
- Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity.BMC genomics · 2019Article
- A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits.BMC biology · 2019Article
- Patterns of Transmission Ratio Distortion in Interspecific Lettuce Hybrids Reveal a Sex-Independent Gametophytic Barrier.Genetics · 2019Article
- Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
In the Bateson-Dobzhansky-Muller (BDM) model of speciation, incompatibilities emerge from the deleterious interactions between alleles that are neutral or advantageous in the original genetic backgrounds, i.e., negative epistatic effects. Within species such interactions are responsible for outbreeding depression and F2 (hybrid) breakdown. We sought to identify BDM incompatibilities in the nematode Caenorhabditis elegans by looking for genomic regions that disrupt egg laying; a complex, highly regulated, and coordinated phenotype. Investigation of introgression lines and recombinant inbred lines derived from the isolates CB4856 and N2 uncovered multiple incompatibility quantitative trait loci (QTL). These QTL produce a synthetic egg-laying defective phenotype not seen in CB4856 and N2 nor in other wild isolates. For two of the QTL regions, results are inconsistent with a model of pairwise interaction between two loci, suggesting that the incompatibilities are a consequence of complex interactions between multiple loci. Analysis of additional life history traits indicates that the QTL regions identified in these screens are associated with effects on other traits such as lifespan and reproduction, suggesting that the incompatibilities are likely to be deleterious. Taken together, these results indicate that numerous BDM incompatibilities that could contribute to reproductive isolation can be detected and mapped within C. elegans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.