Evidence map›Paper›PMID 25128432›Full record

ReviewNeuropsychologia2014

The construct of the multisensory temporal binding window and its dysregulation in developmental disabilities.

Mark T Wallace, Ryan A Stevenson

Registry-linked trialAbstract readReview
In one paragraph

Review in Neuropsychologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07182331 (Effects of cTBS on Sensory Integration in Children With Autism Spectrum Disorder), which is not on this map. Cited by 154 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07182331 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Effects of cTBS on Sensory Integration in Children With Autism Spectrum Disorder: A Randomized, Sham-Controlled Study Integrating Genetic Markers, MRI, fNIRS, and Temporal Binding Tasks

TypeinterventionalSponsorNeurolab PlusRan2025 to 2026Enrolled40ConditionsAutism Spectrum Disorder (ASD)ArmsContinuous Theta Burst Stimulation to Bilateral DLPFC, Sham Continuous Theta Burst Stimulation
3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Time perception and autistic spectrum condition: A systematic review.Autism research : official journal of the International Society for Autism Research · 2019
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Staged Audiovisual Speech Integration and Altered Early-Stage Audiovisual Processing in Autistic Children: An EEG Investigation.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  11. Article
  12. Article
  13. The rhythm of sensory input shapes audio-visual temporal processing.British journal of psychology (London, England : 1953) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Learning impairments in Fmr1Journal of neurodevelopmental disorders · 2025
    Article
  20. Article

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark T WallaceVanderbilt Brain Institute, Vanderbilt University, 465 21st Avenue South, Nashville, TN 37232, USA; Department of Hearing & Speech Sciences, Vanderbilt University, Nashville, TN, USA; Department of Psychology, Vanderbilt University, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University, Nashville, TN, USA. Electronic address: mark.wallace@vanderbilt.edu.
Ryan A StevensonDepartment of Psychology, University of Toronto, Toronto, ON, Canada.

Funding

Evaluation of Sensory Integration Treatment in ASDR34DC010927 · NIDCD · VANDERBILT UNIVERSITY · PI CAMARATA, STEPHEN MARK, WALLACE, MARK THOMAS · 2009 to 2010
$682k
Multisensory Processing Across Lifespan and Links to CognitionR21CA183492 · NCI · VANDERBILT UNIVERSITY · PI NEWHOUSE, PAUL A., WALLACE, MARK THOMAS · 2013 to 2014
$416k
NCI NIH HHS R21 CA183492NIDCD NIH HHS R34 DC010927
6 · The paper itself

Abstract

Behavior, perception and cognition are strongly shaped by the synthesis of information across the different sensory modalities. Such multisensory integration often results in performance and perceptual benefits that reflect the additional information conferred by having cues from multiple senses providing redundant or complementary information. The spatial and temporal relationships of these cues provide powerful statistical information about how these cues should be integrated or "bound" in order to create a unified perceptual representation. Much recent work has examined the temporal factors that are integral in multisensory processing, with many focused on the construct of the multisensory temporal binding window - the epoch of time within which stimuli from different modalities is likely to be integrated and perceptually bound. Emerging evidence suggests that this temporal window is altered in a series of neurodevelopmental disorders, including autism, dyslexia and schizophrenia. In addition to their role in sensory processing, these deficits in multisensory temporal function may play an important role in the perceptual and cognitive weaknesses that characterize these clinical disorders. Within this context, focus on improving the acuity of multisensory temporal function may have important implications for the amelioration of the "higher-order" deficits that serve as the defining features of these disorders.

Indexed as

Auditory PerceptionCognitionCuesDevelopmental DisabilitiesHumansReaction TimeVisual PerceptionAutismCrossmodalDyslexiaMultisensorySchizophreniaTemporal

Identifiers

PMID25128432
PMCPMC4326640

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.