ArticleAge (Dordrecht, Netherlands)2014
Strength training reduces circulating interleukin-6 but not brain-derived neurotrophic factor in community-dwelling elderly individuals.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A Meta-Analysis of the Effects of Different Exercise Modes on Inflammatory Response in the Elderly.International journal of environmental research and public health · 2022Pooled it
- The effect of physical exercise on circulating brain-derived neurotrophic factor in healthy subjects: A meta-analysis of randomized controlled trials.Brain and behavior · 2022Pooled it
- The Impact of Different Types of Exercise Training on Peripheral Blood Brain-Derived Neurotrophic Factor Concentrations in Older Adults: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Trial
- Acute effects of strength and endurance exercise on serum BDNF and IGF-1 levels in older men.BMC geriatrics · 2021Trial
- Effects of Horticultural Therapy on Asian Older Adults: A Randomized Controlled Trial.International journal of environmental research and public health · 2018Trial
- Effects of resistance training at different loads on inflammatory markers in young adults.European journal of applied physiology · 2017Trial
- Trial
- Effects of Strength Training on Cognitive Function, Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 in Highly-Trained Young Female Soccer Players.Sports medicine - open · 2026Article
- Theoretical Perspectives on Balance Training and the Gut-Muscle-Brain Axis in Aging.Brain sciences · 2026Review
- Effects and mechanisms of different exercise modalities on inflammation in older adults, particularly with sarcopenia: a narrative review.Frontiers in medicine · 2026Review
- Resistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Model.Life (Basel, Switzerland) · 2025Article
- Resisting decline: the neuroprotective role of resistance exercise in supporting cerebrovascular function and brain health in aging.Frontiers in physiology · 2025Review
- Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.BMJ open · 2024Article
- Effects of acute aerobic exercise on brain-derived neurotrophic factor level in rheumatoid arthritis patients.Archives of rheumatology · 2023Article
- Long-term exercise training and inflammatory biomarkers in healthy subjects: a meta-analysis of randomized controlled trials.Frontiers in psychology · 2023Review
- Effects of Sport Stacking on Neuropsychological, Neurobiological, and Brain Function Performances in Patients With Mild Alzheimer's Disease and Mild Cognitive Impairment: A Randomized Controlled Trial.Frontiers in aging neuroscience · 2022Article
- Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults.BMC neuroscience · 2021Article
- Article
- Resistance Exercise Intensity Does Not Influence Neurotrophic Factors Response in Equated Volume Schemes.Journal of human kinetics · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ageing is associated with a chronic low-grade inflammatory profile (CLIP). Physical exercise could circumvent the deleterious effects of CLIP by influencing circulating inflammatory mediators and neurotrophic growth factors. This study aimed at assessing whether 12 weeks of progressive strength training (PST) influences circulating brain-derived neurotrophic factor (BDNF), interleukin (IL)-6 and IL-10 in elderly individuals. Forty community-dwelling persons aged 62-72 years participated. Twenty participants were assigned to 12-week PST (70-80 % of maximal strength, three times per week). Matched control individuals (n = 20) maintained daily activity levels. Serum was collected for BDNF, IL-6 and IL-10 assay from all participants before and after 12 weeks (for PST subjects 24-48 h after the last training). In PST, muscle strength was significantly improved (+49 % for leg extension, p = 0.039), and basal IL-6 levels significantly reduced (p = 0.001), which remained unchanged in control (p = 0.117). No significant change in BDNF was observed in PST subjects (p = 0.147) or control (p = 0.563). IL-10 was below the detection limit in most subjects. Gender and health status did not influence the results. Our results show that after 12-week PST, muscle performance improved significantly, and basal levels of IL-6 were significantly decreased in older subjects. However, serum BDNF was not altered. The lack of an observable change in BDNF might be due to a short-lived BDNF response, occurring acutely following exercise, which might have been washed out when sampling. Furthermore, blood levels of BDNF may not reflect parallel increases that occur locally in the brain and muscle. These hypotheses need confirmation by further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.