Evidence map›Paper›PMID 25127917›Full record

ArticlePediatric nephrology (Berlin, Germany)2015

The diagnosis of febrile urinary tract infection in children may be facilitated by urinary biomarkers.

Hahn-Ey Lee, Do Kyun Kim, Hee Kyung Kang, Kwanjin Park

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03163394 (HD5 Levels in Catheter Versus Bag Urine Specimens in Young Children for the Diagnosis of UTI), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03163394 terminatednot on this mapstarted 2017, after this paper: background citation

HD5 Levels in Catheter Versus Bag Urine Specimens in Young Children for the Diagnosis of UTI

TypeobservationalSponsorLe Bonheur Children's HospitalRan2017 to 2019Enrolled5ConditionsUrinary Tract Infections
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Urinary tract infections in children: Testing a novel, noninvasive, point-of-care diagnostic marker.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2022
    Article
  8. Biomarkers for febrile urinary tract infection in children.Pediatric nephrology (Berlin, Germany) · 2022
    Article
  9. Article
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  11. Article
  12. Article
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  14. Review
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  16. Article
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  18. Article
  19. Urinary Tract Infection in Children.Recent patents on inflammation & allergy drug discovery · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hahn-Ey LeeDepartment of Urology, Gachon University Gil Medical Center, Gachon University, 1198 Guwol 1-dong, Namdong-gu, Incheon, Korea.
Do Kyun Kim
Hee Kyung Kang
Kwanjin Park
Seoul National University · KRGachon University · KRSeoul National University Children's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe prospectively assessed the feasibility of two urinary markers of renal injury as potential diagnostic tests for acute febrile urinary tract infection (UTI) and subsequent renal scarring.

methodsThe patient cohort comprised children aged 0 to 4 years who visited the emergency room. The children were divided into three groups, namely, a febrile UTI (fUTI), febrile control (FC) and a non-febrile control (NFC) group, respectively, which were matched for sex and age. An enzyme-linked immunosorbent assay for neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) was performed on urine collected from each child. The urine levels of both markers were compared between the three groups, and the diagnostic accuracy was determined based on the area under the receiver-operator characteristic curve (AUC). In the fUTI group, the predictability of subsequent renal scarring was assessed by associating urinary levels with dimercaptosuccinic acid findings 6 months after an UTI episode.

resultsSignificantly elevated levels of urinary NGAL and KIM-1 were observed in the fUTI group, as well as with increased urine esterase, serum C-reactive protein, and pyuria. The AUC was 72 % for KIM-1 and 96 % for NGAL. The AUC of KIM-1 for the prediction of scarring was 71 % (p < 0.05).

conclusionsThe diagnosis of febrile UTI and the prediction of subsequent scarring may be facilitated by assaying urine biomarkers with acceptable accuracy.

Indexed as

Area Under CurveBiomarkersChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleFeverHumansInfantInfant, NewbornMaleROC CurveSensitivity and SpecificityUrinary Tract InfectionsBiomarkers

Identifiers

PMID25127917
OpenAlexW2117607403

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.