ArticleLeukemia research2014
The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).
Article in Leukemia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Polypharmacy and Malnutrition Management of Elderly Perioperative Patients with Cancer: A Systematic Review.Nutrients · 2021Pooled it
- Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis.The oncologist · 2020Pooled it
- Trial
- Trial
- Poxvirus Vectored Cytomegalovirus Vaccine to Prevent Cytomegalovirus Viremia in Transplant Recipients: A Phase 2, Randomized Clinical Trial.Annals of internal medicine · 2020Trial
- Methodological Development and Assessing Prescribing Determinants Through Cumulative Drug Exposure in Hospitalized Patients: Proof-of-Concept Retrospective Study.JMIR medical informatics · 2026Article
- Polypharmacy and quality of life in Yemeni cancer patients undergoing chemotherapy: A cross-sectional study.PLOS global public health · 2026Article
- Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity.Journal of the American Geriatrics Society · 2025Article
- Association of potentially inappropriate medications with prognosis among older patients with non-small cell lung cancer.BMC geriatrics · 2024Article
- Decreasing polypharmacy in older adults with cancer: A pilot cluster-randomized trial protocol.Journal of geriatric oncology · 2024Article
- Polypharmacy and potentially inappropriate medicine use in older adults with cancer: a multicenter cross-sectional study in Northwest Ethiopia oncologic centers.Journal of pharmaceutical policy and practice · 2024Article
- Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus-specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis.American journal of hematology · 2023Article
- Considerations and analysis of the implementation of oncogeriatrics in Chile and its importance: Review of current literature.Frontiers in aging · 2023Review
- Dynamic changes in physical function during intensive chemotherapy affect transplant outcomes in older adults with AML.Frontiers in oncology · 2023Article
- Association of Polypharmacy and Potentially Inappropriate Medications With Frailty Among Older Adults With Blood Cancers.Journal of the National Comprehensive Cancer Network : JNCCN · 2022Article
- Dose intensity for induction in acute myeloid leukemia: what, when, and for whom?Haematologica · 2021Article
- Prevalence and effects of polypharmacy on overall survival in acute myeloid leukemia.Leukemia & lymphoma · 2020Article
- Geriatric assessment among older adults receiving intensive therapy for acute myeloid leukemia: Report of CALGB 361006 (Alliance).Journal of geriatric oncology · 2020Article
- Delivering intensive therapies to older adults with hematologic malignancies: strategies to personalize care.Hematology. American Society of Hematology. Education Program · 2019Article
- Polypharmacy in Patients with Ovarian Cancer.The oncologist · 2019Article
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9 authors at 2 institutions in 1 country.
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Abstract
We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (≥ 4 versus ≤ 1) was associated with increased 30-day mortality (OR=9.98, 95% CI=1.18-84.13), lower odds of complete remission status (OR=0.20, 95% CI=0.06-0.65), and higher overall mortality (HR=2.13, 95% CI=1.15-3.92). Inappropriate medication use (classified according to Beers criteria) was not significantly associated with clinical outcomes. Polypharmacy warrants further study as a modifiable marker of vulnerability among older adults with AML.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.