ArticlePloS one2014
Benign and malignant nodular thyroid disease in acromegaly. Is a routine thyroid ultrasound evaluation advisable?
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Thyroid abnormalities in acromegaly in the era of improved disease control: a two-stage study.Journal of endocrinological investigation · 2026Article
- Cancer screening in patients with acromegaly: a plea for a personalized approach and international registries.Reviews in endocrine & metabolic disorders · 2025Review
- Incidence and risk factors of cancers in acromegaly: a Chinese single-center retrospective study.Endocrine · 2023Article
- Review
- A rare case of Cushing's disease concurrent with papillary thyroid carcinoma.Caspian journal of internal medicine · 2021Article
- Cosecreting TSH/GH pituitary adenomas-an 8-year experience in a single tertiary center.Pituitary · 2020Article
- Acromegaly and ultrasound: how, when and why?Journal of endocrinological investigation · 2020Review
- Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes.The Journal of clinical endocrinology and metabolism · 2019Article
- Article
- Health-Related Complications of Acromegaly-Risk of Malignant Neoplasms.Frontiers in endocrinology · 2019Review
- Breakdown of Autonomously Functioning Thyroid Nodule Accompanied by Acromegaly After Octreotide Treatment.Frontiers in endocrinology · 2019Article
- Large-Scale Comparative Analysis Reveals A Simple Model To Predict The Prevalence Of Thyroid Nodules.Risk management and healthcare policy · 2019Article
- GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly.International journal of endocrinology · 2018Article
- A case of a co-secreting TSH and growth hormone pituitary adenoma presenting with a thyroid nodule.Endocrinology, diabetes & metabolism case reports · 2018Article
- Acromegaly: clinical features at diagnosis.Pituitary · 2017Review
- Usefulness of an ad hoc questionnaire (Acro-CQ) for the systematic assessment of acromegaly comorbidities at diagnosis and their management at follow-up.Journal of endocrinological investigation · 2016Article
- An Epidemiological Study of Risk Factors of Thyroid Nodule and Goiter in Chinese Women.International journal of environmental research and public health · 2015Article
- An epidemiological study of risk factors of thyroid nodule and goiter in Chinese women.International journal of clinical and experimental medicine · 2015Article
- Thyroid gland changes in patients with acromegaly.Archives of endocrinology and metabolismArticle
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data on the prevalence of benign and malignant nodular thyroid disease in patients with acromegaly is a matter of debate. In the last decade an increasing incidence of thyroid cancer has been reported. The aim of this study was to evaluate the prevalence of goiter, thyroid nodules and thyroid cancer in a large series of patients with acromegaly with a cross-sectional study with a control group. Six Spanish university hospitals participated. One hundred and twenty three patients (50% men; mean age 59±13 years; disease duration 6.7±7.2 years) and 50 controls (51% males, mean age 58±15 years) were studied. All participants underwent thyroid ultrasound and fine needle aspiration. Cytological analysis was performed in suspicious nodules between 0.5 and 1.0 cm and in all nodules greater than 1.0 cm. Goiter was more frequently found in patients than in controls (24.9 vs. 8.3%, respectively; p<0.001). Nodular thyroid disease as well as nodules greater than 1 cm were also more prevalent in acromegalic patients (64.6%, vs. 28.6%, p<0.05 and 53.3 vs. 28.6%, respectively; p<0.05), and all underwent fine needle aspiration. Suspicious cytology was detected in 4 patients and in none of the controls. After thyroidectomy, papillary thyroid carcinoma was confirmed in two cases (3.3% of patients with thyroid nodules), representing 1.6% of the entire group of patients with acromegaly (2.4% including a case with previously diagnosed papillary thyroid carcinoma). These data indicated that thyroid nodular disease and cancer are increased in acromegaly, thus justifying its routine ultrasound screening.
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