ReviewSeizure2014
Clinical correlates of graph theory findings in temporal lobe epilepsy.
Review in Seizure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 71 citations in OpenAlex.
- Alterations of the brain network in idiopathic rapid eye movement sleep behavior disorder: structural connectivity analysis.Sleep & breathing = Schlaf & Atmung · 2019Trial
- The network neuropsychology of juvenile myoclonic epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Distinct neural patterns for various information in working memory: A brain connectivity study.PloS one · 2025Article
- Predictors of long-term memory and network connectivity 10 years after anterior temporal lobe resection.Epilepsia · 2024Article
- Electroencephalography derived connectivity informing epilepsy surgical planning: Towards clinical applications and future perspectives.NeuroImage. Clinical · 2024Review
- Connectome-based disentangling of epilepsy networks from insular stereoelectroencephalographic leads.Frontiers in neurology · 2024Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Perspectives on Understanding Aberrant Brain Networks in Epilepsy.Frontiers in network physiology · 2022Article
- Resting-State MEG Source Space Network Metrics Associated with the Duration of Temporal Lobe Epilepsy.Brain topography · 2021Article
- Alterations of the intrinsic amygdala-hippocampal network in juvenile myoclonic epilepsy.Brain and behavior · 2021Article
- Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis.Brain and behavior · 2021Article
- Changes in the Functional Brain Network of Children Undergoing Repeated Epilepsy Surgery: An EEG Source Connectivity Study.Diagnostics (Basel, Switzerland) · 2021Article
- Dynamic functional connectivity in temporal lobe epilepsy: a graph theoretical and machine learning approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Characteristic Alterations of Network in Patients With Intraoperative Stimulation-Induced Seizures During Awake Craniotomy.Frontiers in neurology · 2021Article
- Functional Network Alterations as Markers for Predicting the Treatment Outcome of Cathodal Transcranial Direct Current Stimulation in Focal Epilepsy.Frontiers in human neuroscience · 2021Article
- [Connectivity pattern of action potentials causal network in prefrontal cortex during anxiety].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Tonic Resting State Hubness Supports High Gamma Activity Defined Verbal Memory Encoding Network in Epilepsy.Neuroscience · 2020Article
- Alterations in the metabolic networks of temporal lobe epilepsy patients: A graph theoretical analysis using FDG-PET.NeuroImage. Clinical · 2020Article
- Global brain network dynamics predict therapeutic responsiveness to cannabidiol treatment for refractory epilepsy.Brain communications · 2020Article
- Aberrant Metabolic Patterns Networks in Insular Epilepsy.Frontiers in neurology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTemporal lobe epilepsy (TLE) is considered a brain network disorder, additionally representing the most common form of pharmaco-resistant epilepsy in adults. There is increasing evidence that seizures in TLE arise from abnormal epileptogenic networks, which extend beyond the clinico-radiologically determined epileptogenic zone and may contribute to the failure rate of 30-50% following epilepsy surgery. Graph theory allows for a network-based representation of TLE brain networks using several neuroimaging and electrophysiologic modalities, and has potential to provide clinicians with clinically useful biomarkers for diagnostic and prognostic purposes.
methodsWe performed a review of the current state of graph theory findings in TLE as they pertain to localization of the epileptogenic zone, prediction of pre- and post-surgical seizure frequency and cognitive performance, and monitoring cognitive decline in TLE.
resultsAlthough different neuroimaging and electrophysiologic modalities have yielded occasionally conflicting results, several potential biomarkers have been characterized for identifying the epileptogenic zone, pre-/post-surgical seizure prediction, and assessing cognitive performance. For localization, graph theory measures of centrality have shown the most potential, including betweenness centrality, outdegree, and graph index complexity, whereas for prediction of seizure frequency, measures of synchronizability have shown the most potential. The utility of clustering coefficient and characteristic path length for assessing cognitive performance in TLE is also discussed.
conclusionsFuture studies integrating data from multiple modalities and testing predictive models are needed to clarify findings and develop graph theory for its clinical utility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.