ArticleThe Journal of clinical endocrinology and metabolism2014
Reduced levels of plasma kisspeptin during the antenatal booking visit are associated with increased risk of miscarriage.
Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03940495 (A Prospective Study to Evaluate Whether Serum Kisspeptin is a Marker Predictive of the First Trimester Miscarriage of Women Who Conceive in IVF), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Study to Evaluate Whether Serum Kisspeptin is a Marker Predictive of the First Trimester Miscarriage of Women Who Conceive in IVF
Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- Kisspeptin modulates sexual and emotional brain processing in humans.The Journal of clinical investigation · 2017Trial
- Effect of Exogenous Danio rerio kiss1 Peptide on Cortisol Levels in Early Embryos and Juvenile Forms of Teleost Fish.Bulletin of experimental biology and medicine · 2026Article
- Kisspeptin as a Precision Biomarker in Personalized Pharmacy: Implications for Individualized Monitoring of Early Pregnancy Viability.Pharmacy (Basel, Switzerland) · 2026Review
- The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.International journal of molecular sciences · 2026Review
- Exploring the Role of Kisspeptin in Polycystic Ovary Syndrome and Its Associated Pregnancy Complications.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Kisspeptin and neurokinin B: roles in reproductive health.Physiological reviews · 2025Review
- Understanding Host-Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches.Pathogens (Basel, Switzerland) · 2025Review
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.Endocrine reviews · 2024Review
- Associations between maternal urinary kisspeptin in late pregnancy and decreased fetal growth: a pregnancy-birth cohort study.Frontiers in endocrinology · 2024Article
- A prospective study to evaluate whether serum kisspeptin is a marker predictive of the first-trimester miscarriage of women who conceive in IVF.Journal of assisted reproduction and genetics · 2024Article
- KISS1 Gene Variations and Susceptibility to Idiopathic Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Biomarkers at 6 weeks' gestation in the prediction of early miscarriage in pregnancy following assisted reproductive technology.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Changes in circulating forms of anti-Muüllerian hormone and androgens in women with and without PCOS: a systematic longitudinal study throughout pregnancy.Human reproduction (Oxford, England) · 2023Article
- The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review.International journal of molecular sciences · 2022Review
- Kisspeptins and Glucose Homeostasis in Pregnancy: Implications for Gestational Diabetes Mellitus-a Review Article.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Human Chorionic Gonadotropin and Early Embryogenesis: Review.International journal of molecular sciences · 2022Review
- Kisspeptin in the Prediction of Pregnancy Complications.Frontiers in endocrinology · 2022Review
- Changes in Circulating Kisspeptin Levels During Each Trimester in Women With Antenatal Complications.The Journal of clinical endocrinology and metabolism · 2022Article
- Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester.Fertility and sterility · 2021Article
- From inhibition of trophoblast cell invasion to proapoptosis: what are the potential roles of kisspeptins in preeclampsia?American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
contextKisspeptin is a recently identified hormone encoded by the KISS1 gene, playing a critical role in human reproduction. Plasma kisspeptin levels rise dramatically during normal pregnancy due to placental synthesis, which implicates it as a potential tool for assessing risks of pregnancy complications. No previous prospective study has investigated the association between plasma kisspeptin and risk of miscarriage.
objectiveThe objective of the study was to determine whether a single plasma kisspeptin or serum human chorionic gonadotropin (hCG) measurement in asymptomatic women attending their booking antenatal visit is associated with miscarriage.
designThis was a prospective cohort study.
settingThe study was conducted at a tertiary obstetric center.
participantsA total of 993 asymptomatic pregnant women with a gestation of 6 weeks or longer attending routine antenatal booking visit were recruited between January 2010 and December 2012.
main outcome measuresPlasma kisspeptin and serum hCG were measured during the antenatal booking visit. Pregnancy outcome was recorded prospectively.
resultsPlasma kisspeptin correlated with gestation (r(2) = 0.57; P < .0001). Gestational age-corrected (multiples of median) plasma kisspeptin was 60.4% lower (P < .001), and multiples of median-hCG was 36.1% lower (P < .001) in women later diagnosed with miscarriage compared with women without miscarriage. Increased plasma kisspeptin was associated with reduced miscarriage risk, even after adjusting for age, body mass index, gestational age, smoking, and blood pressure [odds ratio 0.13 (95% confidence interval 0.08-0.22), P = .0001]. Kisspeptin had a higher diagnostic performance for miscarriage than hCG (receiver-operator characteristic-area under the curve 0.899 ± 0.025 plasma kisspeptin; 0.775 ± 0.040, serum hCG, P < .01 vs plasma kisspeptin).
conclusionOur data suggest for the first time that a single plasma kisspeptin measurement taken during the antenatal booking visit provides a potential novel marker for identifying asymptomatic pregnant women at a gestation of 6 weeks or greater at increased risk of miscarriage.
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