ArticleCell reports2014
Costs and benefits of mutational robustness in RNA viruses.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Phylogenetic and Proteomic Analyses of Segment 2 Sequence Reveals the Presence of Two Variants of a Divergent Amnoonvirus (Family:Microorganisms · 2026Article
- Spillover: Mechanisms, Genetic Barriers, and the Role of Reservoirs in Emerging Pathogens.Microorganisms · 2024Review
- Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection.Virus evolution · 2024Article
- A tradeoff between enterovirus A71 particle stability and cell entry.Nature communications · 2023Article
- Quasispecies Nature of RNA Viruses: Lessons from the Past.Vaccines · 2023Review
- MicroRNA-detargeting proves more effective thanMolecular therapy oncolytics · 2021Article
- Ribozyme Mutagenic Evolution: Mechanisms of Survival.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Effects of historical co-infection on host shift abilities of exploitative and competitive viruses.Evolution; international journal of organic evolution · 2021Article
- Why are viral genomes so fragile? The bottleneck hypothesis.PLoS computational biology · 2021Article
- Intra-host evolutionary dynamics of the hepatitis C virus among people who inject drugs.Scientific reports · 2021Article
- COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy.Human genomics · 2021Review
- The evolutionary origin of the universal distribution of mutation fitness effect.PLoS computational biology · 2021Article
- Comprehensive analysis of genomic diversity of SARS-CoV-2 in different geographic regions of India: an endeavour to classify Indian SARS-CoV-2 strains on the basis of co-existing mutations.Archives of virology · 2021Article
- An Evolutionary Model of Progression to AIDS.Microorganisms · 2020Article
- Adaptation of turnip mosaic potyvirus to a specific niche reduces its genetic and environmental robustness.Virus evolution · 2020Article
- Review
- Developing Picornaviruses for Cancer Therapy.Cancers · 2019Review
- Article
- Inferring population genetics parameters of evolving viruses using time-series data.Virus evolution · 2019Article
- Mutational load causes stochastic evolutionary outcomes in acute RNA viral infection.Virus evolution · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The accumulation of mutations in RNA viruses is thought to facilitate rapid adaptation to changes in the environment. However, most mutations have deleterious effects on fitness, especially for viruses. Thus, tolerance to mutations should determine the nature and extent of genetic diversity that can be maintained in the population. Here, we combine population genetics theory, computer simulation, and experimental evolution to examine the advantages and disadvantages of tolerance to mutations, also known as mutational robustness. We find that mutational robustness increases neutral diversity and, as expected, can facilitate adaptation to a new environment. Surprisingly, under certain conditions, robustness may also be an impediment for viral adaptation, if a highly diverse population contains a large proportion of previously neutral mutations that are deleterious in the new environment. These findings may inform therapeutic strategies that cause extinction of otherwise robust viral populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.