ArticleCell reports2014
A pseudouridine residue in the spliceosome core is part of the filamentous growth program in yeast.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 87 citations in OpenAlex.
- Ψ-Atlas: An Integrated Atlas for Pseudouridine Epitranscriptome.Genomics, proteomics & bioinformatics · 2026Article
- Integrative Genomic Analysis Reveals Pseudouridine Modification-Related Gene Signatures Associated With Prognosis and Therapeutic Response Patterns in Hepatocellular Carcinoma.International journal of genomics · 2026Article
- Article
- Definer: A computational method for accurate identification of RNA pseudouridine sites based on deep learning.PloS one · 2025Article
- Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives.Clinical and translational medicine · 2025Review
- Quantitative detection of pseudouridine in RNA by mass spectrometry.Scientific reports · 2024Article
- U6 snRNA m6A modification is required for accurate and efficient splicing of C. elegans and human pre-mRNAs.Nucleic acids research · 2024Article
- Truncated protein isoforms generate diversity of protein localization and function in yeast.Cell systems · 2024Article
- Review
- Fuzzy kernel evidence Random Forest for identifying pseudouridine sites.Briefings in bioinformatics · 2024Article
- Interpretable Multi-Scale Deep Learning for RNA Methylation Analysis across Multiple Species.International journal of molecular sciences · 2024Article
- The emerging role of epitranscriptome in shaping stress responses in plants.Plant cell reports · 2023Review
- The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1.PloS one · 2023Article
- PseU-ST: A new stacked ensemble-learning method for identifying RNA pseudouridine sites.Frontiers in genetics · 2023Article
- Predicting Pseudouridine Sites with Porpoise.Methods in molecular biology (Clifton, N.J.) · 2023Article
- meLife · 2022Article
- The plant epitranscriptome: revisiting pseudouridine and 2'-O-methyl RNA modifications.Plant biotechnology journal · 2022Review
- Genome-Wide Identification and Expression Analysis of Pseudouridine Synthase Family inInternational journal of molecular sciences · 2022Article
- A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing.Molecular cancer · 2022Article
- The epitranscriptome of small non-coding RNAs.Non-coding RNA research · 2021Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), they are not known to have physiologic roles in cell differentiation. We have identified a pseudouridine residue (Ψ28) on spliceosomal U6 snRNA that is induced during filamentous growth of Saccharomyces cerevisiae. Pus1p catalyzes this modification and is upregulated during filamentation. Several U6 snRNA mutants are strongly pseudouridylated at Ψ28. Remarkably, these U6 mutants activate pseudohyphal growth, dependent upon Pus1p, arguing that U6-Ψ28 per se can initiate at least part of the filamentous growth program. We confirmed this by using a designer small nucleolar RNA (snoRNA) targeting U6-U28 pseudouridylation. Conversely, mutants that block U6-U28 pseudouridylation inhibit pseudohyphal growth. U6-U28 pseudouridylation changes the splicing efficiency of suboptimal introns; thus, Pus1p-dependent pseudouridylation of U6 snRNA contributes to the filamentation growth program.
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Registered trials
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