ArticlePloS one2014
Automated segmentation and quantification of white matter hyperintensities in acute ischemic stroke patients with cerebral infarction.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Deep optimization-guided hybrid neural network for accurate detection and segmentation of white matter hyperintensities in clinical MRI images.Scientific reports · 2026Article
- Article
- APOE4 modulates the association between DTI-ALPS index and Alzheimer's pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Automated rating of Fazekas scale in fluid-attenuated inversion recovery MRI for ischemic stroke or transient ischemic attack using machine learning.Scientific reports · 2025Article
- Daily fluid intake and brain amyloid deposition: A cohort study.Journal of Alzheimer's disease : JAD · 2025Article
- Segmenting Small Stroke Lesions with Novel Labeling Strategies.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025Article
- Cerebral small vessel disease lesion segmentation methods: A systematic review.Cerebral circulation - cognition and behavior · 2025Review
- Visual and Auditory Sensory Impairments Differentially Relate with Alzheimer's Pathology.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities.Alzheimer's research & therapy · 2024Article
- Modulatory Effect of Blood LDL Cholesterol on the Association between Cerebral Aβ and Tau Deposition in Older Adults.The journal of prevention of Alzheimer's disease · 2024Article
- Serum Adiponectin and In Vivo Brain Amyloid Deposition in Cognitively Normal Older Adults: A Cohort Study.Aging and disease · 2023Article
- Circadian rest-activity rhythm and longitudinal brain changes underlying late-life cognitive decline.Psychiatry and clinical neurosciences · 2023Article
- Enlarged perivascular spaces are associated with decreased brain tau deposition.CNS neuroscience & therapeutics · 2023Article
- Low Ankle-Brachial Index Relates to Alzheimer-Signature Cerebral Glucose Metabolism in Cognitively Impaired Older Adults.Journal of Alzheimer's disease : JAD · 2023Article
- Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.Journal of Alzheimer's disease : JAD · 2023Article
- Association of low meal frequency with decreasediScience · 2022Article
- Spouse bereavement and brain pathologies: A propensity score matching study.Psychiatry and clinical neurosciences · 2022Article
- Serum zinc levels and in vivo beta-amyloid deposition in the human brain.Alzheimer's research & therapy · 2021Article
- Segmentation of white matter hyperintensities onEuropean journal of nuclear medicine and molecular imaging · 2021Article
- Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.Journal of neuroscience methods · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter hyperintensities (WMHs) of presumed vascular origin are common in ageing population, especially in patients with acute cerebral infarction and the volume has been reported to be associated with mental impairment and the risk of hemorrhage from antithrombotic agents. WMHs delineation can be computerized to minimize human bias. However, the presence of cerebral infarcts greatly degrades the accuracy of WMHs detection and thus limits the application of computerized delineation to patients with acute cerebral infarction. We propose a computer-assisted segmentation method to depict WMHs in the presence of cerebral infarcts in combined T1-weighted, fluid attenuation inversion recovery, and diffusion-weighted magnetic resonance imaging (MRI). The proposed method detects WMHs by empirical threshold and atlas information, with subtraction of white matter voxels affected by acute infarction. The method was derived using MRI from 25 hemispheres with WMHs only and 13 hemispheres with both WMHs and cerebral infarcts. Similarity index (SI) and correlation were utilized to assess the agreement between the new automated method and a gold standard visually guided semi-automated method done by an expert rater. The proposed WMHs segmentation approach produced average SI, sensitivity and specificity of 83.142±11.742, 84.154±16.086 and 99.988±0.029% with WMHs only and of 68.826±14.036, 74.381±18.473 and 99.956±0.054% with both WMHs and cerebral infarcts in the derivation cohort. The performance of the proposed method with an external validation cohort was also highly consistent with that of the experienced rater.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.