ArticlePloS one2014
Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Gene polymorphisms of pro-inflammatory cytokines may affect the risk of Graves' disease: a meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Association ofBioscience reports · 2018Pooled it
- Promoter Polymorphism (-174, G/C) of Interleukin-6 and Arterial Thromboembolic Events: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Medical Applications of Molecular Biotechnologies in the Context of Hashimoto's Thyroiditis.Diagnostics (Basel, Switzerland) · 2023Review
- Assessment of serum dipeptidyl peptidase-IV levels in autoimmune thyroid disease.The Journal of international medical research · 2022Article
- In Search for the Missing Link in APECED-like Conditions: Analysis of theJournal of clinical medicine · 2022Article
- Associations between gut microbiota and thyroidal function status in Chinese patients with Graves' disease.Journal of endocrinological investigation · 2021Article
- Hashimoto's thyroiditis following SARS-CoV-2 infection.BMJ case reports · 2021Article
- Interaction of Genetic Variations inThyroid : official journal of the American Thyroid Association · 2019Article
- Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy.Scientific reports · 2018Article
- Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease.International journal of endocrinology · 2018Article
- The Association BetweenFrontiers in genetics · 2018Article
- Association between polymorphism within interleukin related genes and Graves' disease: a meta-analysis of 22 case-control studies.Oncotarget · 2017Article
- Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population.Rheumatology international · 2017Article
- Hepatitis C Virus E2 Protein Induces Upregulation of IL-8 Pathways and Production of Heat Shock Proteins in Human Thyroid Cells.The Journal of clinical endocrinology and metabolism · 2017Article
- Observational
- Lower Serum 25-Hydroxyvitamin D Level is Associated With 3 Types of Autoimmune Thyroid Diseases.Medicine · 2015Observational
- Role of genetic and non-genetic factors in the etiology of Graves' disease.Journal of endocrinological investigation · 2015Review
- Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases.Journal of immunology research · 2015Article
- Article
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11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutoimmune thyroid disease (AITD) comprises diseases including Hashimoto's thyroiditis and Graves' disease, both characterized by reactivity to autoantigens causing, respectively, inflammatory destruction and autoimmune stimulation of the thyroid-stimulating hormone receptor. AITD is the most common thyroid disease and the leading form of autoimmune disease in women. Cytokines are key regulators of the immune and inflammatory responses; therefore, genetic variants at cytokine-encoding genes are potential risk factors for AITD.
methodsPolymorphisms in the IL6-174 G/C (rs1800795), TNFA-308 G/A (rs1800629), IL1B-511 C/T (rs16944), and IFNGR1-56 T/C (rs2234711) genes were assessed in a case-control study comprising 420 Hashimoto's thyroiditis patients, 111 Graves' disease patients and 735 unrelated controls from Portugal. Genetic variants were discriminated by real-time PCR using TaqMan SNP genotyping assays.
resultsA significant association was found between the allele A in TNFA-308 G/A and Hashimoto's thyroiditis, both in the dominant (OR = 1.82, CI = 1.37-2.43, p-value = 4.4×10(-5)) and log-additive (OR = 1.64, CI = 1.28-2.10, p-value = 8.2×10(-5)) models. The allele C in IL6-174 G/C is also associated with Hashimoto's thyroiditis, however, only retained significance after multiple testing correction in the log-additive model (OR = 1.28, CI = 1.06-1.54, p-value = 8.9×10(-3)). The group with Graves' disease also registered a higher frequency of the allele A in TNFA-308 G/A compared with controls both in the dominant (OR = 1.85, CI = 1.19-2.87, p-value = 7.0×10(-3)) and log-additive (OR = 1.69, CI = 1.17-2.44, p-value = 6.6×10(-3)) models. The risk for Hashimoto's thyroiditis and Graves' disease increases with the number of risk alleles (OR for two risk alleles is, respectively, 2.27 and 2.59).
conclusionsThis study reports significant associations of genetic variants in TNFA and IL6 with the risk for AITD, highlighting the relevance of polymorphisms in inflammation-related genes in the etiopathogenesis of AITD.
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