Evidence map›Paper›PMID 25127084›Full record

Trial reportPsychoneuroendocrinology2014

Effect of restorative yoga vs. stretching on diurnal cortisol dynamics and psychosocial outcomes in individuals with the metabolic syndrome: the PRYSMS randomized controlled trial.

Sarah M Corey, Elissa Epel, Michael Schembri, Sarah B Pawlowsky, Roger J Cole, Maria Rosario G Araneta, Elizabeth Barrett-Connor, Alka M Kanaya

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Use of Salivary Diurnal Cortisol as an Outcome Measure in Randomised Controlled Trials: a Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
    Pooled it
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  13. Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah M CoreyUniversity of California, San Francisco, CA 94115, USA. Electronic address: sarahmcorey@yahoo.com.
Elissa EpelUniversity of California, San Francisco, CA 94115, USA.
Michael SchembriUniversity of California, San Francisco, CA 94115, USA.
Sarah B PawlowskySan Francisco State University, San Francisco, CA 94132, USA.
Roger J ColeSynchrony Applied Health Sciences, Del Mar, CA 92014, USA.
Maria Rosario G AranetaUniversity of California, San Diego, CA 92093, USA.
Elizabeth Barrett-ConnorUniversity of California, San Diego, CA 92093, USA.
Alka M KanayaUniversity of California, San Francisco, CA 94115, USA.

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) studyR01AT004569 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2009 to 2012
$2.1M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
NCATS NIH HHS UL1 TR000004NCCIH NIH HHS 5R01AT004569-02NCCIH NIH HHS R01 AT004569NCCIH NIH HHS T32 AT003997NCRR NIH HHS UL1 RR024131NHLBI NIH HHS K24 HL112827
6 · The paper itself

Abstract

purposeChronic stimulation and dysregulation of the neuroendocrine system by stress may cause metabolic abnormalities. We estimated how much cortisol and psychosocial outcomes improved with a restorative yoga (relaxation) versus a low impact stretching intervention for individuals with the metabolic syndrome.

methodsWe conducted a 1-year multi-center randomized controlled trial (6-month intervention and 6-month maintenance phase) of restorative yoga vs. stretching. Participants completed surveys to assess depression, social support, positive affect, and stress at baseline, 6 months and 12 months. For each assessment, we collected saliva at four points daily for three days and collected response to dexamethasone on the fourth day for analysis of diurnal cortisol dynamics. We analyzed our data using multivariate regression models, controlling for study site, medications (antidepressants, hormone therapy), body mass index, and baseline cortisol values.

resultsPsychosocial outcome measures were available for 171 study participants at baseline, 140 at 6 months, and 132 at 1 year. Complete cortisol data were available for 136 of 171 study participants (72 in restorative yoga and 64 in stretching) and were only available at baseline and 6 months. At 6 months, the stretching group had decreased cortisol at waking and bedtime compared to the restorative yoga group. The pattern of changes in stress mirrored this improvement, with the stretching group showing reductions in chronic stress severity and perseverative thoughts about their stress. Perceived stress decreased by 1.5 points (-0.4; 3.3, p=0.11) at 6 months, and by 2.0 points (0.1; 3.9, p=0.04) at 1 year in the stretching compared to restorative yoga groups. Post hoc analyses suggest that in the stretching group only, perceived increases in social support (particularly feelings of belonging), but not changes in stress were related to improved cortisol dynamics.

conclusionsWe found significant decreases in salivary cortisol, chronic stress severity, and stress perception in the stretching group compared to the restorative yoga group. Group support during the interactive stretch classes may have contributed to these changes.

Indexed as

Muscle Stretching ExercisesAdultAffectAgedCircadian RhythmDepressionDexamethasoneFemaleHumansHydrocortisoneMaleMetabolic SyndromeMiddle AgedPituitary-Adrenal Function TestsSalivaSocial SupportDexamethasoneHydrocortisoneDexamethasoneDiurnal cortisolMetabolic syndromeSocial supportStressWaking cortisol

Identifiers

PMID25127084
PMCPMC4174464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.