ReviewJournal of immunology research2014
The relevance of HLA sequencing in population genetics studies.
Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- HLA Alleles and Haplotype Distribution Across Russian Population Groups.International journal of molecular sciences · 2026Article
- HLA Genetics for the Human Diseases.Advances in experimental medicine and biology · 2024Review
- High Resolution HLA ∼A, ∼B, ∼C, ∼DRB1, ∼DQA1, and ∼DQB1 Diversity in South African Populations.Frontiers in genetics · 2022Article
- Haplotypic Associations and Differentiation of MHC Class II Polymorphic Alu Insertions at Five Loci With HLA-DRB1 Alleles in 12 Minority Ethnic Populations in China.Frontiers in genetics · 2021Article
- Concordance between predicted HLA type using next generation sequencing data generated for non-HLA purposes and clinical HLA type.Human immunology · 2020Article
- HLA-A, -B, -C, -DRB1, -DQA1, and -DQB1 allele and haplotype frequencies defined by next generation sequencing in a population of East Croatia blood donors.Scientific reports · 2020Article
- High-resolution characterization of allelic and haplotypic HLA frequency distribution in a Spanish population using high-throughput next-generation sequencing.Human immunology · 2019Article
- The distribution of HLA haplotypes in the ethnic groups that make up the Brazilian Bone Marrow Volunteer Donor Registry (REDOME).Immunogenetics · 2018Article
- Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios.BMC bioinformatics · 2018Article
- A genomic perspective on HLA evolution.Immunogenetics · 2018Review
- Article
- Analysis of sequence data to identify potential risk variants for oral clefts in multiplex families.Molecular genetics & genomic medicine · 2017Article
- HLAscan: genotyping of the HLA region using next-generation sequencing data.BMC bioinformatics · 2017Article
- T-cell epitopes predicted from the Nucleocapsid protein of Sin Nombre virus restricted to 30 HLA alleles common to the North American population.Bioinformation · 2017Article
- HLA imputation in an admixed population: An assessment of the 1000 Genomes data as a training set.Human immunology · 2016Article
- An Efficient Multiple-Testing Adjustment for eQTL Studies that Accounts for Linkage Disequilibrium between Variants.American journal of human genetics · 2016Article
- Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping via next generation sequencing.Human immunology · 2015Article
- Granuloma genes in sarcoidosis: what is new?Current opinion in pulmonary medicine · 2015Review
- Forward-in-Time, Spatially Explicit Modeling Software to Simulate Genetic Lineages Under Selection.Evolutionary bioinformatics online · 2015Article
- Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?Journal of immunology research · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Next generation sequencing (NGS) is currently being adapted by different biotechnological platforms to the standard typing method for HLA polymorphism, the huge diversity of which makes this initiative particularly challenging. Boosting the molecular characterization of the HLA genes through efficient, rapid, and low-cost technologies is expected to amplify the success of tissue transplantation by enabling us to find donor-recipient matching for rare phenotypes. But the application of NGS technologies to the molecular mapping of the MHC region also anticipates essential changes in population genetic studies. Huge amounts of HLA sequence data will be available in the next years for different populations, with the potential to change our understanding of HLA variation in humans. In this review, we first explain how HLA sequencing allows a better assessment of the HLA diversity in human populations, taking also into account the methodological difficulties it introduces at the statistical level; secondly, we show how analyzing HLA sequence variation may improve our comprehension of population genetic relationships by facilitating the identification of demographic events that marked human evolution; finally, we discuss the interest of both HLA and genome-wide sequencing and genotyping in detecting functionally significant SNPs in the MHC region, the latter having also contributed to the makeup of the HLA molecular diversity observed today.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.