Evidence map›Paper›PMID 25126585›Full record

ReviewJournal of immunology research2014

Cellular factors targeting APCs to modulate adaptive T cell immunity.

Anabelle Visperas, Jeongsu Do, Booki Min

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Immunity and Coagulation in COVID-19.International journal of molecular sciences · 2024
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anabelle VisperasDepartment of Immunology/NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA ; Department of Molecular Medicine, Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.ORCID 0000-0001-5431-3916
Jeongsu DoDepartment of Immunology/NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Booki MinDepartment of Immunology/NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA ; Department of Molecular Medicine, Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.
Cleveland Clinic · US

Funding

Homeostatic Regulation of T LymphocytesR01AI074932 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI MIN, BOOKI · 2009 to 2013
$1.9M
Molecular Medicine Training ProgramT32GM088088 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI SMITH, JONATHAN D · 2011 to 2020
$1.7M
NIAID NIH HHS R01 AI074932NIAID NIH HHS R01-AI074932NIGMS NIH HHS T32 GM088088NIGMS NIH HHS T32-GM088088
6 · The paper itself

Abstract

The fate of adaptive T cell immunity is determined by multiple cellular and molecular factors, among which the cytokine milieu plays the most important role in this process. Depending on the cytokines present during the initial T cell activation, T cells become effector cells that produce different effector molecules and execute adaptive immune functions. Studies thus far have primarily focused on defining how these factors control T cell differentiation by targeting T cells themselves. However, other non-T cells, particularly APCs, also express receptors for the factors and are capable of responding to them. In this review, we will discuss how APCs, by responding to those cytokines, influence T cell differentiation and adaptive immunity.

Indexed as

Adaptive ImmunityImmunomodulationAnimalsAntigen-Presenting CellsCell DifferentiationCytokinesHumansLymphocyte ActivationT-Lymphocyte SubsetsCytokines

Identifiers

PMID25126585
PMCPMC4122108
OpenAlexW2123164867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.